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Statistic
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Details for phenotype: positive regulation of gastric acid secretion
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EndoNet ID: ENP00528
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Name
positive regulation of gastric acid secretion
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of gastric acid secretion
MeSH term
68005744
Phenotype triggers
normal activity of
CCK-2
ui-button
in
oxyntic_cell_of_gastric_gland
ui-button
The CCK2 receptor stimulate the acid secretion from parietal cells in the digestive system.
[1]
CCK-2R is necessary to respond to carbachol as well as to produce the maximal acid secretion. The role of CCK-1R in acid secretion is less important.
[2]
H2
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in
oxyntic_cell_of_gastric_gland
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Because histamine represents a potent stimulant for gastric acid secretion, H2-receptor antagonists are widely used for the treatment of acid-related peptic disease.
[3]
M3
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in
oxyntic_cell_of_gastric_gland
ui-button
Cholinergic stimulation of gastric acid secretion is clearly mediated by the M3 receptor.
[4]
Reference