Details for phenotype: positive regulation of gastric acid secretion

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EndoNet ID: ENP00528

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Name

positive regulation of gastric acid secretion

General information

This phenotype is not pathologic

Links to other resources

GO	positive regulation of gastric acid secretion
MeSH term	68005744

Phenotype triggers

• normal activity of CCK-2 ui-button
  in oxyntic_cell_of_gastric_gland ui-button
  • The CCK2 receptor stimulate the acid secretion from parietal cells in the digestive system. [1]
  • CCK-2R is necessary to respond to carbachol as well as to produce the maximal acid secretion. The role of CCK-1R in acid secretion is less important. [2]
• H2 ui-button
  in oxyntic_cell_of_gastric_gland ui-button
  • Because histamine represents a potent stimulant for gastric acid secretion, H2-receptor antagonists are widely used for the treatment of acid-related peptic disease. [3]
• M3 ui-button
  in oxyntic_cell_of_gastric_gland ui-button
  • Cholinergic stimulation of gastric acid secretion is clearly mediated by the M3 receptor. [4]

EndoNet at the Institut for Bioinformatics UMG Göttingen