Details for phenotype: negative regulation of bile acid biosynthetic process

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EndoNet ID: ENP00553

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Name

negative regulation of bile acid biosynthetic process

General information

This phenotype is not pathologic

Links to other resources

GO	negative regulation of bile acid biosynthetic process
MeSH term	68001647

Phenotype triggers

• normal activity of VDR ui-button
  in hepatocyte ui-button
  • Lithocholic acid acetate or 1α, 25-dihydroxy-vitamin D3-activated VDR strongly inhibites cholesterol 7α-hydroxylase mRNA expression and reduces bile acid synthesis in human hepatocytes. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen