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Statistic
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Details for phenotype: heart development
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EndoNet ID: ENP00558
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Name
heart development
General information
This phenotype is not pathologic
Links to other resources
GO
heart development
MeSH term
Organogenesis
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 1
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in
smooth_muscle_cell
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Direct evidence for S1P receptor signaling in angiogenesis and cardiovascular development comes from the phenotype of genetic-null studies in mice. The s1p1-null embryos die in utero because of defective vascular maturation in which VSMCs/pericytes do not migrate to surround the vessels.
[1]
normal activity of
Vascular endothelial growth factor receptor 1
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in
heart
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Moderate overexpression of VEGF1 from its endogenous locus results in aberrant heart development and lethality at E12.5-14, which shows essential role of regulated signalling during development.
[2]
normal activity of
Sphingosine 1-phosphate receptor 2
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in
heart
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A zebrafish mutation in the mil gene indicates a role of S1P2 receptor in the development of the cardiovascular system. Mutants showed a defective migration of the cardiac muscle progenitor cells from lateral positions to the midline resulting in the development of two hearts.
[3]
Reference