Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: heart development
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00558
Add to network
Name
heart development
General information
This phenotype is not pathologic
Links to other resources
GO
heart development
MeSH term
Organogenesis
Phenotype triggers
normal activity of
Sphingosine 1-phosphate receptor 1
ui-button
in
smooth_muscle_cell
ui-button
Direct evidence for S1P receptor signaling in angiogenesis and cardiovascular development comes from the phenotype of genetic-null studies in mice. The s1p1-null embryos die in utero because of defective vascular maturation in which VSMCs/pericytes do not migrate to surround the vessels.
[1]
normal activity of
Vascular endothelial growth factor receptor 1
ui-button
in
heart
ui-button
Moderate overexpression of VEGF1 from its endogenous locus results in aberrant heart development and lethality at E12.5-14, which shows essential role of regulated signalling during development.
[2]
normal activity of
Sphingosine 1-phosphate receptor 2
ui-button
in
heart
ui-button
A zebrafish mutation in the mil gene indicates a role of S1P2 receptor in the development of the cardiovascular system. Mutants showed a defective migration of the cardiac muscle progenitor cells from lateral positions to the midline resulting in the development of two hearts.
[3]
Reference
