Status
Please wait ...

Details for phenotype: hematopoiesis

EndoNet ID: ENP00559

Name

hematopoiesis

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68006410

Phenotype triggers

  • normal activity of Vascular endothelial growth factor receptor 1
    in bone_marrow
    • Inhibition of VEGFR1, but not VEGFR2, blockes HSC cell cycling, differentiation and hematopoietic recovery after bone marrow suppression. Placental growth factor (PlGF), which signals through VEGFR1, restored early and late phases of hematopoiesis following bone marrow suppression. PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative bone marrow microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis. [1]
  • FLT3
    in hematopoietic_stem_cell
    • The accumulated data clearly point to FLT3 as an important receptor in early hematopoiesis. [2]
Reference