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Statistic
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Details for phenotype: negative regulation of cell volume
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EndoNet ID: ENP00565
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Name
negative regulation of cell volume
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of cell volume
MeSH term
68004847
Phenotype triggers
normal activity of
TrpV4-A
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in
epithelial_cell
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TRPV4 channel is the only pathway mediating the swelling-activated Ca2+ entry required to achieve a full RVD in human tracheal epithelial cells.
[1]
Human airway epithelia show a typical Ca2+-dependent cell regularoty volume decrease (RVD) under hypotonic conditions.
[2]
Impaired RVD response in Cystic Fibrosis airway epithelia is caused by a misregulation of TRPV4, suggesting that hypotonic activation of TRPV4 channels is cystic fibrosis transmembrane conductance regulator-dependent.
[1]
Reference
