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Statistic
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Details for phenotype: thermoception
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EndoNet ID: ENP00567
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Name
thermoception
General information
This phenotype is not pathologic
Links to other resources
GO
thermoception
MeSH term
68013697
Phenotype triggers
normal activity of
TrpV4-A
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in
keratinocyte
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TRPV4 is essential for the desensitizing warmth-evoked current responses.
[1]
Keratinocytes can detect warm temperatures by mechanisms that are apparently TRPV4-dependent.
[1]
normal activity of
trkA
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in
dorsal_root_ganglion
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Neuroanatomical examinatio of the PNS of mice lacking trkA revealed extensive neuronal cell loss in trigeminal, dorsal root, and sympathetic ganglia.
[2]
Mice lacking the trkA exhibit deficiencies in thermoception.
[3]
Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system.
[3]
Reference