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Details for phenotype: thermoception

EndoNet ID: ENP00567

Name

thermoception

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68013697

Phenotype triggers

  • normal activity of TrpV4-A
    in keratinocyte
    • TRPV4 is essential for the desensitizing warmth-evoked current responses. [1]
    • Keratinocytes can detect warm temperatures by mechanisms that are apparently TRPV4-dependent. [1]
  • normal activity of trkA
    in dorsal_root_ganglion
    • Neuroanatomical examinatio of the PNS of mice lacking trkA revealed extensive neuronal cell loss in trigeminal, dorsal root, and sympathetic ganglia. [2]
    • Mice lacking the trkA exhibit deficiencies in thermoception. [3]
    • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [3]
Reference