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Details for phenotype: regulation of iron ion transmembrane transport

EndoNet ID: ENP00577

Name

regulation of iron ion transmembrane transport

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68000042

Phenotype triggers

  • normal activity of transferrin receptor 1
    in hepatocyte
    • Absorbed iron is bound to circulating transferrin and passes initially through the portal system of the liver, which is the major site of iron storage. Hepatocytes take up transferrin-bound iron via the classical transferrin receptor (TfR1) but likely in greater amounts by the homologous protein, TfR2. [1]
  • normal activity of transferrin receptor 2
    in platelet
    • TfR2 binds diferric transferrin (Tf) and can mediate the uptake of Tf-bound iron into cells. TfR2 serves as a receptor for Tf-bound iron in human platelets. [2]
    • Hemochromatosis protein can influence cellular iron levels. The body iron status can alter platelet count, size and activation. [3]
    • Platelets contain hemochromatosis protein, and also TfR2 was detectable in platelets. [4]
  • normal activity of transferrin receptor 2
    in duodenum
    • TfR2 is a key regulatory molecule that interacts functionally with Hemochromatosis Gene Product in a specialized pathway controlling iron absorption in mammals. The localization and molecular interactions of endogenous Hemochromatosis Gene Product and TfR2 proteins was examined in human and murine intestinal tissue and cells. [5]
  • normal activity of transferrin receptor 1
    in cell_of_syncytiotrophoblast
    • A developing fetus needs a lot of iron, which is transferred across the human placenta. Iron uptake at the apical membrane of the syncytiotrophoblast occurs via TfR-mediated endocytosis of maternal iron. [6]
    • Hemochromatosis factor regulates TfR-mediated iron uptake. TfR and hemochromatosis factor, as well as TfR and divalent metal transporter-1 interact in placental trophoblast cells. [7]
Reference