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Statistic
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Details for phenotype: regulation of iron ion transmembrane transport
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EndoNet ID: ENP00577
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Name
regulation of iron ion transmembrane transport
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of iron ion transmembrane transport
MeSH term
68000042
Phenotype triggers
normal activity of
transferrin receptor 1
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in
hepatocyte
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Absorbed iron is bound to circulating transferrin and passes initially through the portal system of the liver, which is the major site of iron storage. Hepatocytes take up transferrin-bound iron via the classical transferrin receptor (TfR1) but likely in greater amounts by the homologous protein, TfR2.
[1]
normal activity of
transferrin receptor 2
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in
platelet
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TfR2 binds diferric transferrin (Tf) and can mediate the uptake of Tf-bound iron into cells. TfR2 serves as a receptor for Tf-bound iron in human platelets.
[2]
Hemochromatosis protein can influence cellular iron levels. The body iron status can alter platelet count, size and activation.
[3]
Platelets contain hemochromatosis protein, and also TfR2 was detectable in platelets.
[4]
normal activity of
transferrin receptor 2
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in
duodenum
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TfR2 is a key regulatory molecule that interacts functionally with Hemochromatosis Gene Product in a specialized pathway controlling iron absorption in mammals. The localization and molecular interactions of endogenous Hemochromatosis Gene Product and TfR2 proteins was examined in human and murine intestinal tissue and cells.
[5]
normal activity of
transferrin receptor 1
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in
cell_of_syncytiotrophoblast
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A developing fetus needs a lot of iron, which is transferred across the human placenta. Iron uptake at the apical membrane of the syncytiotrophoblast occurs via TfR-mediated endocytosis of maternal iron.
[6]
Hemochromatosis factor regulates TfR-mediated iron uptake. TfR and hemochromatosis factor, as well as TfR and divalent metal transporter-1 interact in placental trophoblast cells.
[7]
Reference