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Statistic
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Details for phenotype: involvement in liver steatosis
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EndoNet ID: ENP00632
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Name
involvement in liver steatosis
General information
This phenotype is pathologic
Links to other resources
GO
positive regulation of lipid storage
Disease database
29786
Phenotype triggers
more activity (high ligand concentration, overexpression) of
PPARgamma1
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in
lipocyte_of_liver
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Among genes involved in lipid metabolism, adipogenesis-related genes, PPARgamma and its targeted gene, CD36 mRNA expression is specifically up-regulated in the liver by high fat diet for 2 weeks. Protein expression of cAMP response element-binding protein (CREB), an upstream molecule of PPARgamma, in the liver was drastically suppressed by high fat diet.
[1]
CREB-PPARgamma signaling pathway could be involved in the high fat diet-induced liver steatosis.
[1]
Reference
