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Details for phenotype: regulation of tissue remodeling

EndoNet ID: ENP00634

Name

regulation of tissue remodeling

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68054338

Phenotype triggers

  • normal activity of angiotensin receptor 2
    in lipocyte_of_liver
    • The renin-angiotensin system plays an important role in hepatic fibrogenesis. After activation, human hepatic stellate cells express the components of the renin-angiotensin system and synthesize angiotensin II,which lead to the suggestions that locally generated angiotensin II could participate in tissue remodeling in the human liver. [1]
  • normal activity of PDGFRbeta
    in lipocyte_of_liver
    • Dominant-negative soluble PDGF-beta receptor is active as an antifibrogenic protein drug able to reduce the biological effects of PDGF in ongoing fibrogenesis. Therefore, it could be an attractive therapeutic agent for the treatment of fibrotic liver diseases and possibly other fibrotic organ lesions. [2]
    • PDGF plays a critical role in the progression and initiation of experimental liver fibrogenesis, it is important for the activation into a myofibroblastic phenotype. [3]
  • normal activity of PDGFR
    in lipocyte_of_liver
    • Dominant-negative soluble PDGF-beta receptor is active as an antifibrogenic protein drug able to reduce the biological effects of PDGF in ongoing fibrogenesis. Therefore, it could be an attractive therapeutic agent for the treatment of fibrotic liver diseases and possibly other fibrotic organ lesions. [2]
    • PDGF plays a critical role in the progression and initiation of experimental liver fibrogenesis, it is important for the activation into a myofibroblastic phenotype. [3]
Reference