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Statistic
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Details for phenotype: regulation of tissue remodeling
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EndoNet ID: ENP00634
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Name
regulation of tissue remodeling
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of tissue remodeling
MeSH term
68054338
Phenotype triggers
normal activity of
angiotensin receptor 2
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in
lipocyte_of_liver
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The renin-angiotensin system plays an important role in hepatic fibrogenesis. After activation, human hepatic stellate cells express the components of the renin-angiotensin system and synthesize angiotensin II,which lead to the suggestions that locally generated angiotensin II could participate in tissue remodeling in the human liver.
[1]
normal activity of
PDGFRbeta
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in
lipocyte_of_liver
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Dominant-negative soluble PDGF-beta receptor is active as an antifibrogenic protein drug able to reduce the biological effects of PDGF in ongoing fibrogenesis. Therefore, it could be an attractive therapeutic agent for the treatment of fibrotic liver diseases and possibly other fibrotic organ lesions.
[2]
PDGF plays a critical role in the progression and initiation of experimental liver fibrogenesis, it is important for the activation into a myofibroblastic phenotype.
[3]
normal activity of
PDGFR
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in
lipocyte_of_liver
ui-button
Dominant-negative soluble PDGF-beta receptor is active as an antifibrogenic protein drug able to reduce the biological effects of PDGF in ongoing fibrogenesis. Therefore, it could be an attractive therapeutic agent for the treatment of fibrotic liver diseases and possibly other fibrotic organ lesions.
[2]
PDGF plays a critical role in the progression and initiation of experimental liver fibrogenesis, it is important for the activation into a myofibroblastic phenotype.
[3]
Reference