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Statistic
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Details for phenotype: positive regulation of cell proliferation and apotosis
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EndoNet ID: ENP00643
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Name
positive regulation of cell proliferation and apotosis
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of cell proliferation
positive regulation of apoptosis
MeSH term
68002454
Phenotype triggers
normal activity of
EGFR isoform a
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in
lipocyte_of_liver
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In quiescent HSC, hydrophobic bile acids activate the EGFR, and this can couple to both cell proliferation and apoptosis, depending on the JNK signaling. Therefore, JNK act as a switch between bile acid-induced proliferation and apoptosis in HSC.
[1]
Reference
