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Statistic
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Details for phenotype: positive regulation of fatty acid oxidation
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EndoNet ID: ENP00650
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Name
positive regulation of fatty acid oxidation
General information
This phenotype is not pathologic
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GO
positive regulation of fatty acid oxidation
MeSH term
68005227
Phenotype triggers
normal activity of
leptin receptor
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in
skeleton_muscle
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Leptin promotes fatty acid (FA) oxidation in skeletal muscle through activation of AMP-activated protein kinase which, in turn, phosphorylates and inhibits acetyl-coenzyme A carboxylase, leading to reduced malonyl-coenzyme A and increased FA flux into the mitochondria via carnitine palmitoyl transferase-1.
[1]
Reference
