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Statistic
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Details for phenotype: positive regulation of ossification
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EndoNet ID: ENP00687
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Name
positive regulation of ossification
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of bone ossification
Phenotype triggers
normal activity of
ER-alpha
ui-button
in
osteoclast
ui-button
Activation of Er alpha results in preserved tickness and number of trabeculae and preserved thickness and volumetric density of cortical bone.
[1]
ER alpha but not ER beta or AR is of importance for the trabecular bone-sparing effect of estrogens.
[1]
normal activity of
ER-alpha
ui-button
in
growth_plate
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ER alpha is expressed in the growth-plate cartilage and in bone.
[1]
In aging men, estradiol is the dominant sex steroid regulating bone resorption, whereas both estradiol and testosterone are important in maintaining bone formation.
[2]
normal activity of
ER-beta
ui-button
in
growth_plate
ui-button
ER beta is expressed in the growth-plate cartilage and in bone.
[1]
In aging men, estradiol is the dominant sex steroid regulating bone resorption, whereas both estradiol and testosterone are important in maintaining bone formation.
[2]
Reference
