Details for phenotype: ectodomain shedding

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EndoNet ID: ENP00705

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Name

ectodomain shedding

General information

This phenotype is not pathologic

Links to other resources

GO	membrane protein ectodomain proteolysis

Phenotype triggers

• normal activity of ADAM17 ui-button
  in neutrophil_granulocyte ui-button
  • ADAM17 deficient neutrophils failed to shed L-selectin in response to PMA. [1]
• normal activity of ADAM17 ui-button
  in monocyte ui-button
  • ADAM17 deficient monocytes failed to shed L-selectin in response to PMA. [1]
• normal activity of ADAM17 ui-button
  in T-lymphocyte ui-button
  • ADAM17 deficient lymphocytes failed to shed L-selectin in response to PMA. [1]

EndoNet at the Institut for Bioinformatics UMG Göttingen