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Statistic
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Details for phenotype: regulation of inhibitory postsynaptic membrane potential
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EndoNet ID: ENP00707
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Name
regulation of inhibitory postsynaptic membrane potential
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of inhibitory postsynaptic membrane potential
Phenotype triggers
normal activity of
alpha-2A adrenoreceptor
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in
Golgi_cell
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Alpha 2a subtype modulates activity of golgi cells (inhibitory interneurons) according to states of vigilance.
[1]
normal activity of
alpha-2B adrenoreceptor
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in
Golgi_cell
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Alpha 2b AR subtype provides modulation of golgi cells appropriate to the strength of glutamatergic input.
[1]
normal activity of
alpha 1D-adrenoreceptor
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in
dentate_nucleus
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Alpha 1D ARs are constitutively active in association with other endogenous recetors to modulate the activity of dentate nucleus neurons.
[1]
normal activity of
alpha-2A adrenoreceptor
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in
Purkinje_cell
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Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential.
[2]
normal activity of
alpha-2B adrenoreceptor
ui-button
in
Purkinje_cell
ui-button
Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential.
[2]
normal activity of
alpha-2C adrenoreceptor
ui-button
in
Purkinje_cell
ui-button
Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential.
[2]
normal activity of
alpha 1A-adrenoreceptor
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in
Purkinje_cell
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Alpha 1A ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells.
[1]
normal activity of
alpha 1B-adrenoreceptor
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in
Purkinje_cell
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Alpha 1B ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells.
[1]
Reference