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Details for phenotype: regulation of inhibitory postsynaptic membrane potential

EndoNet ID: ENP00707

Name

regulation of inhibitory postsynaptic membrane potential

General information

This phenotype is not pathologic

Links to other resources

GO

Phenotype triggers

  • normal activity of alpha-2A adrenoreceptor
    in Golgi_cell
    • Alpha 2a subtype modulates activity of golgi cells (inhibitory interneurons) according to states of vigilance. [1]
  • normal activity of alpha-2B adrenoreceptor
    in Golgi_cell
    • Alpha 2b AR subtype provides modulation of golgi cells appropriate to the strength of glutamatergic input. [1]
  • normal activity of alpha 1D-adrenoreceptor
    in dentate_nucleus
    • Alpha 1D ARs are constitutively active in association with other endogenous recetors to modulate the activity of dentate nucleus neurons. [1]
  • normal activity of alpha-2A adrenoreceptor
    in Purkinje_cell
    • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [2]
  • normal activity of alpha-2B adrenoreceptor
    in Purkinje_cell
    • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [2]
  • normal activity of alpha-2C adrenoreceptor
    in Purkinje_cell
    • Alpha 2 AR subtypes are expressed in the cerebellar cortex including Purkinje cells and may play a role in motor coordination. Presynaptic activation of alpha 2-ARs inhibits cerebellar inhibitory synaptic transmission and therefore negatively regulates inhibitory postsynaptic membrane potential. [2]
  • normal activity of alpha 1A-adrenoreceptor
    in Purkinje_cell
    • Alpha 1A ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [1]
  • normal activity of alpha 1B-adrenoreceptor
    in Purkinje_cell
    • Alpha 1B ARs may play a role in the timing and receipt of the inhibitory signals from Purkinje cells. [1]
Reference