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Statistic
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Details for phenotype: negative regulation of synaptic transmission, GABAergic
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EndoNet ID: ENP00708
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Name
negative regulation of synaptic transmission, GABAergic
General information
This phenotype is not pathologic
Links to other resources
GO
negative regulation of synaptic transmission, GABAergic
Phenotype triggers
normal activity of
alpha 1A-adrenoreceptor
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in
basket_cell
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Basket cells express abundant alpha 1a AR mRNA. Parallel fibers excitation of basket cell dendrites produces off-beam GABAergic inhibition of Purkinje cells.
[1]
normal activity of
alpha 1B-adrenoreceptor
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in
cerebellar_cortex
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Inner stellate cells express moderate levels of alpha 1b AR mRNA. Excitation of stellate cells though parallel fibers produces GABAergic inhibition of Purkinje cells.
[1]
Ability of the alpha 1b AR subtype tp react faster and to lower levels of norepinephrine may be important in the selective inhibition by stellate cells of specific populations of Purkinje cells.
[1]
Reference