Details for phenotype: diabetic glomerulosclerosis

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EndoNet ID: ENP00724

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Name

diabetic glomerulosclerosis

General information

This phenotype is not pathologic

Links to other resources

MeSH term	D003928
Disease database	33012

Phenotype triggers

• no activity (knock out experiment or RNAi) of ER-alpha ui-button
  in kidney ui-button
  • Estrogen via stimulation of ER alpha activates signaling pathways and regulates gene in glomerular/mesangiel clls in a manner that is protective against glomerulosclerosis. [1]
  • Estrogen deficiency accelerates the progression of the development of glomerulosclerosis. [2]

EndoNet at the Institut for Bioinformatics UMG Göttingen