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Details for receptor: sialoadhesin

EndoNet ID: ENR00047

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  • sialoadhesin
  • siglec
  • sialic acid-binding Ig-like lectin 1
  • CD169 antigen
  • siglec-1
  • Sn

General information

  • Sn+ cells are a macrophage subset whose accumulation in the kidney correlates with proteinuria and histologic damage. [1]
  • The extracellular region of sialoadhesin is composed of seventeen immunoglobulin-like domains, of which the amino-terminal two are highly-related structurally and functionally to the amino-terminal domains of CD22, myelin associated glycoprotein and CD33. [2]
  • Lectin-like receptor whose expression is restricted to subsets of tissue and inflammatory macrophages. [1]
  • Sialoadhesin is a transmembrane glycoprotein of 185 kDa that mediates cell-cell interactions through recognition of Neu5Ac alpha2,3Gal in glycoconjugates. [2]
  • The receptor is expressed strongly by tissue macrophages in the spleen, lymph node, bone marrow, liver, colon, and lungs. [3]

Links to other resources

UniProt Q9BZZ2
Ensembl ENST00000419548

Binding hormones

  • soluble PSGL-1

Anatomical structures with this receptor

  • macrophage

    Induced phenotypes

    • cell-cell interactions of macrophages during inflammatory reactions
      • aken together, these observations indicate that Sn has evolved primarily to mediate extracellular functions, namely cell-cell or cell-matrix interactions. [3]