Status
Please wait ...

Details for receptor: RAR

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00058

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • retinoic acid receptor
  • RAR

General information

  • Regulation of the CYP 2 family involves nuclear receptors related to the steroid hormone receptor superfamily, such as the constitutive androstane receptor and the retinoic acid receptor. Retinoic acid is a CYP 2C (CYP 2C8) substrate, thus the regulation of CYP 2C8 expression by a receptor that is activated by an endogenous substrate such as retinoic acid is not surprising. CYP 2C9, which is highly homologous to CYP 2C8, is inducible in primary human hepatocytes by xenobiotics including dexamethasone and phenobarbital. [1]
  • RAR builds a heterodimer with RXR.

Links to other resources

Subunit information

RAR-alpha

Sequence 
MASNSSSCP TPGGGHLNG YPVPPYAFF 
FPPMLGGLS PPGALTTLQ HQLPVSGYS 
TPSPATIET QSSSSEEIV PSPPSPPPL 
PRIYKPCFV CQDKSSGYH YGVSACEGC 
KGFFRRSIQ KNMVYTCHR DKNCIINKV 
TRNRCQYCR LQKCFEVGM SKESVRNDR 
NKKKKEVPK PECSESYTL TPEVGELIE 
KVRKAHQET FPALCQLGK YTTNNSSEQ 
RVSLDIDLW DKFSELSTK CIIKTVEFA 
KQLPGFTTL TIADQITLL KAACLDILI 
LRICTRYTP EQDTMTFSD GLTLNRTQM 
HNAGFGPLT DLVFAFANQ LLPLEMDDA 
ETGLLSAIC LICGDRQDL EQPDRVDML 
QEPLLEALK VYVRKRRPS RPHMFPKML 
MKITDLRSI SAKGAERVI TLKMEIPGS 
MPPLIQEML ENSEGLDTL SGQPGGGGR 
DGGGLAPPP GSCSPSLSP SSNRSSPAT 
HSP
UniProt P10276

RAR-beta

Sequence 
TTSGHACPV PAVNGHMTH YPATPYPLL 
FPPVIGGLS LPPLHGLHG HPPPSGCST 
PSPATIETQ STSSEELVP SPPSPLPPP 
RVYKPCFVC QDKSSGYHY GVSACEGCK 
GFFRRSIQK NMIYTCHRD KNCVINKVT 
RNRCQYCRL QKCFEVGMS KESVRNDRN 
KKKKETSKQ ECTESYEMT AELDDLTEK 
IRKAHQETF PSLCQLGKY TTNSSADHR 
VRLDLGLWD KFSELATKC IIKIVEFAK 
RLPGFTGLT IADQITLLK AACLDILIL 
RICTRYTPE QDTMTFSDG LTLNRTQMH 
NAGFGPLTD LVFTFANQL LPLEMDDTE 
TGLLSAICL ICGDRQDLE EPTKVDKLQ 
EPLLEALKI YIRKRRPSK PHMFPKILM 
KITDLRSIS AKGAERVIT LKMEIPGSM 
PPLIQEMLE NSEGHEPLT PSSSGNTAE 
HSPSISPSS VENSGVSQS PLVQ
UniProt P10826

RAR-gamma

Sequence 
MATNKERLF AAGALGPGS GYPGAGFPF 
AFPGALRGS PPFEMLSPS FRGLGQPDL 
PKEMASLSV ETQSTSSEE MVPSSPSPP 
PPPRVYKPC FVCNDKSSG YHYGVSSCE 
GCKGFFRRS IQKNMVYTC HRDKNCIIN 
KVTRNRCQY CRLQKCFEV GMSKEAVRN 
DRNKKKKEV KEEGSPDSY ELSPQLEEL 
ITKVSKAHQ ETFPSLCQL GKYTTNSSA 
DHRVQLDLG LWDKFSELA TKCIIKIVE 
FAKRLPGFT GLSIADQIT LLKAACLDI 
LMLRICTRY TPEQDTMTF SDGLTLNRT 
QMHNAGFGP LTDLVFAFA GQLLPLEMD 
DTETGLLSA ICLICGDRM DLEEPEKVD 
KLQEPLLEA LRLYARRRR PSQPYMFPR 
MLMKITDLR GISTKGAER AITLKMEIP 
GPMPPLIRE MLENPEMFE DDSSQPGPH 
PNASSEDEV PGGQGKGGL KSPA
UniProt P13631

Binding hormones

  • retinoic acid

Anatomical structures with this receptor

  • chondrocyte

    Induced phenotypes

    • skeletal system development
      • The results of our study demonstrate for the first time that chondrocyte maturation in the cartilaginous skeletal elements of chick embryo limbs involves marked changes in RAR gene expression [2]

  • basophil_thyrotroph_cell_of_anterior_pituitary

    Influences

    • negative TSH
      • Retinoic acid plays an important inhibitory role on in vivo secretion of TSH and this effect is unrelated to the thyroid status of the animals. [3]

  • macrophage

    Induced phenotypes

    • Positive regulator of inflammatory cytokine production
      • Inflammatory cytokine production is impaired in RAR-deficient macrophages. [4]
Reference