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Details for receptor: bradykinin receptor B1

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EndoNet ID: ENR00061

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Synonyms

  • bradykinin receptor B1
  • BDKRB1
  • bradykinin receptor 1
  • B1R

General information

  • Expression of the kinin B1 receptor is up-regulated in chronic inflammatory and fibrotic disorders [1]
  • engagement of the kinin B1 receptor contributes to fibrogenesis through increased expression of CTGF [1]
  • Bradykinin (BK) receptors B1 (B1R) and B2 (B2R) were expressed in human osteoblasts (SaM-1) and osteosarcoma (SaOS-2, HOS, and MG-63) cells. [2]
  • n wound repair, activation of the B2 receptor induces a variety of effects, including increased neutrophil proliferation, stimulation of macrophage spreading, release of histamine from mast cells, synthesis of platelet-activating factor and prostaglandins in endothelial cells, release of tachykinin and acetylcholine from sensory nerve endings, increased microvascular permeability, and fibroblast proliferation [1]
  • The B1R and B2R are G protein-coupled receptors that are involved in mediating pain and inflammation, as well as aspects of cardiovascular and respiratory function [3]
  • expression of B1R is induced upon tissue damage, with very low levels detected in healthy tissue [3]

Links to other resources

UniProt P46663
Ensembl ENST00000216629

Subunit information

Sequence 
MASSWPPLE LQSSNQSQL FPQNATACD 
NAPEAWDLL HRVLPTFII SICFFGLLG 
NLFVLLVFL LPRRQLNVA EIYLANLAA 
SDLVFVLGL PFWAENIWN QFNWPFGAL 
LCRVINGVI KANLFISIF LVVAISQDR 
YRVLVHPMA SRRQQRRRQ ARVTCVLIW 
VVGGLLSIP TFLLRSIQA VPDLNITAC 
ILLLPHEAW HFARIVELN ILGFLLPLA 
AIVFFNYHI LASLRTREE VSRTRCGGR 
KDSKTTALI LTLVVAFLV CWAPYHFFA 
FLEFLFQVQ AVRGCFWED FIDLGLQLA 
NFFAFTNSS LNPVIYVFV GRLFRTKVW 
ELYKQCTPK SLAPISSSH RKEIFQLFW 
RN

Binding hormones

  • lysyl-bradykinin
  • des-Arg9 bradykinin
  • bradykinin

Anatomical structures with this receptor

  • osteoblast

    Influences

    • positive PGE2
      • The B2 receptors are linked to a burst of prostanoid release, whereas the B1 receptors mediate a delayed prostaglandin response [4]
    • positive PGI2
    • The angiogenic effect of BK is due to the direct activation of B1 receptor on capillary endothelial cells, which transduces the autocrine up-regulation of FGF-2 by the endogenous activation of the NOS pathway. [5]

  • neutrophil_granulocyte

    Induced phenotypes

    • Neutrophil chemotaxis

  • endothelial_cell

Reference