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Details for receptor: TRH-R

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EndoNet ID: ENR00079

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Synonyms

  • thyrotropin-releasing hormone receptor
  • TRHR
  • TRH-R
  • thyroliberin receptor

General information

  • Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Links to other resources

UniProt P34981
Ensembl ENST00000311762

Subunit information

Sequence 
MENETVSEL NQTQLQPRA VVALEYQVV 
TILLVLIIC GLGIVGNIM VVLVVMRTK 
HMRTPTNCY LVSLAVADL MVLVAAGLP 
NITDSIYGS WVYGYVGCL CITYLQYLG 
INASSCSIT AFTIERYIA ICHPIKAQF 
LCTFSRAKK IIIFVWAFT SLYCMLWFF 
LLDLNISTY KDAIVISCG YKISRNYYS 
PIYLMDFGV FYVVPMILA TVLYGFIAR 
ILFLNPIPS DPKENSKTW KNDSTHQNT 
NLNVNTSNR CFNSTVSSR KQVTKMLAV 
VVILFALLW MPYRTLVVV NSFLSSPFQ 
ENWFLLFCR ICIYLNSAI NPVIYNLMS 
QKFRAAFRK LCNCKQKPT EKPANYSVA 
LNYSVIKES DHFSTELDD ITVTDTYLS 
ATKVSFDDT CLASEVSFS QS
UniProt P34981

Binding hormones

  • TRH

Anatomical structures with this receptor

  • basophil_thyrotroph_cell_of_anterior_pituitary

    Influences

    • positive TSH
    • positive TRH
      • Stimulates thyroid-stimulating hormone (TSH) release from anterior pituitary [1]
    • negative neuromedin B
      • Neuromedin B is downregulated by thyrotropinreleasing hormone (TRH). [2]

    Induced phenotypes

    • Hypothyroidism
      • Tertiary hypothyroidism is the result of an failure of the hypothalamus to produce sufficient thyrotropin-releasing hormone. [3]

  • acidophil_mammotroph_cell_of_anterior_pituitary

    Influences

    • positive PRL

  • cell_of_intermediate_pituitary

    Influences

    • positive MSH
      • In amphibians, TRH stimulates MSH release in vitro and that the action of TRH is not mediated via an inhibition of the release of endogenous dopamine. [4]
      • TRH reverses the inhibitory effect of dopamine on MSH secretion. The effects of TRH and dopamine are additive. Thus, the intracellular events associated with TRH-induced stimulation and dopamine-induced inhibition of MSH release are not linked together. [5]

  • pituitary_gland_of_diencephalon

    Influences

    • positive GH
      • Tri-iodothyronine-induced downregulation of thyrotropin-releasing hormone-binding sites o pituitary membranes (meaning down-regulation of pituitary TRH receptors) inhibits GH secretion. [6]
Reference