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Details for receptor: progesterone receptor

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EndoNet ID: ENR00085

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Synonyms

  • PR
  • PGR
  • progesterone receptor
  • NR3C3

General information

  • PgR in the normal mammary tissue varies with the degree of lobular development, in parallel with cell proliferation. [1]
  • Normal and malignant human endometrium express immunohistochemically progesterone receptor. [2]
  • In the corpus luteum, in the period from ovulation to the mid-secretory phase, PR immunoreactivity was observed in a large number of both the luteinized granulosa and the theca cells. [3]

Links to other resources

UniProt P06401
Ensembl ENST00000325455

Subunit information

isoform B

Sequence 
MTELKAKGP RAPHVAGGP PSPEVGSPL 
LCRPAAGPF PGSQTSDTL PEVSAIPIS 
LDGLLFPRP CQGQDPSDE KTQDQQSLS 
DVEGAYSRA EATRGAGGS SSSPPEKDS 
GLLDSVLDT LLAPSGPGQ SQPSPPACE 
VTSSWCLFG PELPEDPPA APATQRVLS 
PLMSRSGCK VGDSSGTAA AHKVLPRGL 
SPARQLLLP ASESPHWSG APVKPSPQA 
AAVEVEEED GSESEESAG PLLKGKPRA 
LGGAAAGGG AAAVPPGAA AGGVALVPK 
EDSRFSAPR VALVEQDAP MAPGRSPLA 
TTVMDFIHV PILPLNHAL LAARTRQLL 
EDESYDGGA GAASAFAPP RSSPCASST 
PVAVGDFPD CAYPPDAEP KDDAYPLYS 
DFQPPALKI KEEEEGAEA SARSPRSYL 
VAGANPAAF PDFPLGPPP PLPPRATPS 
RPGEAAVTA APASASVSS ASSSGSTLE 
CILYKAEGA PPQQGPFAP PPCKAPGAS 
GCLLPRDGL PSTSASAAA AGAAPALYP 
ALGLNGLPQ LGYQAAVLK EGLPQVYPP 
YLNYLRPDS EASQSPQYS FESLPQKIC 
LICGDEASG CHYGVLTCG SCKVFFKRA 
MEGQHNYLC AGRNDCIVD KIRRKNCPA 
CRLRKCCQA GMVLGGRKF KKFNKVRVV 
RALDAVALP QPVGVPNES QALSQRFTF 
SPGQDIQLI PPLINLLMS IEPDVIYAG 
HDNTKPDTS SSLLTSLNQ LGERQLLSV 
VKWSKSLPG FRNLHIDDQ ITLIQYSWM 
SLMVFGLGW RSYKHVSGQ MLYFAPDLI 
LNEQRMKES SFYSLCLTM WQIPQEFVK 
LQVSQEEFL CMKVLLLLN TIPLEGLRS 
QTQFEEMRS SYIRELIKA IGLRQKGVV 
SSSQRFYQL TKLLDNLHD LVKQLHLYC 
LNTFIQSRA LSVEFPEMM SEVIAAQLP 
KILAGMVKP LLFHKK
UniProt P06401-1

Binding hormones

  • progesterone

Anatomical structures with this receptor

  • corpus_luteum

  • cell_of_endometrium_of_uterus

    Influences

    • negative IL-11
      • Progesterone attenuates IL-11 secretion and mRNA expression. [4]
    • positive TGF-beta 2
      • Northern blot analysis confirmed an increase in TGF-beta 2 mRNA with progesterone treatment. [5]

  • mammary_gland

    Induced phenotypes

    • mammary gland morphogenesis
      • The progesterone receptor exists as two isoforms, PRA and PRB, differing by the length of the N-terminal end and originating from translation reinitiation at an internal methionine codon. Studies with transgenic mice show that the ratio of both forms is essential for proper development of the mammary gland. [6]

  • hypothalamus

    Influences

    • positive GnRH-I
      • ovairan progesterione is essential for the secretion of GnRH, mediated by interaction with cognate intracellular progesterone receptor. [7]

  • ovary

    Induced phenotypes

    • mammary gland development
      • The ovarian steroid hormone progesterone, important for female reproductive functions, including uterine and mammary gland development. [8]
    • maintainance of pregnancy
      • The ovarian steroid hormone progesterone, important for female reproductive functions, including maintainance of pregnancy [8]
    • sexual behavior
      • The ovarian steroid hormone progesterone, important for female reproductive functions, including sexual behavior. [8]
    • regulation of ovulation
      • The ovarian steroid hormone progesterone is important for female reproductive functions, including ovulation. [8]

  • macrophage

Reference