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Details for receptor: ER-alpha:ER-beta

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  • General information
  • Subunits
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EndoNet ID: ENR00093

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Synonyms

  • ER-alpha:ER-beta
  • ER-alpha/beta

General information

  • Have diverse physiological effects in the reproductive system, bone, cardiovascular system, hematopoiesis and central and peripheral nervous systems. [1]
  • ER-alpha and ER-beta are products of different genes and exhibit tissue- and cell-type specific expression. [1]
  • ER-alpha and ER-beta are coexpressed in a number of tissues and can form functional heterodimers. [1]

Links to other resources

Subunit information

ER-alpha (1 times)

Sequence 
MTMTLHTKA SGMALLHQI QGNELEPLN 
RPQLKIPLE RPLGEVYLD SSKPAVYNY 
PEGAAYEFN AAAAANAQV YGQTGLPYG 
PGSEAAAFG SNGLGGFPP LNSVSPSPL 
MLLHPPPQL SPFLQPHGQ QVPYYLENE 
PSGYTVREA GPPAFYRPN SDNRRQGGR 
ERLASTNDK GSMAMESAK ETRYCAVCN 
DYASGYHYG VWSCEGCKA FFKRSIQGH 
NDYMCPATN QCTIDKNRR KSCQACRLR 
KCYEVGMMK GGIRKDRRG GRMLKHKRQ 
RDDGEGRGE VGSAGDMRA ANLWPSPLM 
IKRSKKNSL ALSLTADQM VSALLDAEP 
PILYSEYDP TRPFSEASM MGLLTNLAD 
RELVHMINW AKRVPGFVD LTLHDQVHL 
LECAWLEIL MIGLVWRSM EHPGKLLFA 
PNLLLDRNQ GKCVEGMVE IFDMLLATS 
SRFRMMNLQ GEEFVCLKS IILLNSGVY 
TFLSSTLKS LEEKDHIHR VLDKITDTL 
IHLMAKAGL TLQQQHQRL AQLLLILSH 
IRHMSNKGM EHLYSMKCK NVVPLYDLL 
LEMLDAHRL HAPTSRGGA SVEETDQSH 
LATAGSTSS HSLQKYYIT GEAEGFPAT 
V
UniProt P03372-1

ER-beta (1 times)

Sequence 
MDIKNSPSS LNSPSSYNC SQSILPLEH 
GSIYIPSSY VDSHHEYPA MTFYSPAVM 
NYSIPSNVT NLEGGPGRQ TTSPNVLWP 
TPGHLSPLV VHRQLSHLY AEPQKSPWC 
EARSLEHTL PVNRETLKR KVSGNRCAS 
PVTGPGSKR DAHFCAVCS DYASGYHYG 
VWSCEGCKA FFKRSIQGH NDYICPATN 
QCTIDKNRR KSCQACRLR KCYEVGMVK 
CGSRRERCG YRLVRRQRS ADEQLHCAG 
KAKRSGGHA PRVRELLLD ALSPEQLVL 
TLLEAEPPH VLISRPSAP FTEASMMMS 
LTKLADKEL VHMISWAKK IPGFVELSL 
FDQVRLLES CWMEVLMMG LMWRSIDHP 
GKLIFAPDL VLDRDEGKC VEGILEIFD 
MLLATTSRF RELKLQHKE YLCVKAMIL 
LNSSMYPLV TATQDADSS RKLAHLLNA 
VTDALVWVI AKSGISSQQ QSMRLANLL 
MLLSHVRHA SNKGMEHLL NMKCKNVVP 
VYDLLLEML NAHVLRGCK SSITGSECS 
PAEDSKSKE GSQNPQSQ
UniProt Q92731-1

Binding hormones

  • estradiol

Anatomical structures with this receptor

  • pituitary_gland_of_diencephalon

    Influences

    • negative LH
      • In female ER alpha knock out mice, disruption of the negative feedback actions of estradiol in the hypothalamic-pituitary axisresults in elevated levels of the gonadotropin subunit mRNAs in the pituitary and in serum LH. [2]

  • basophil_gonadotroph_cell_of_anterior_pituitary_FSH

    Influences

    • negative FSH
      • Regulation of FSH release is through negative feedback of gonadal steroids, particularly estradiol, which act directly at the pituitary.
Reference