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Details for receptor: CD28

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EndoNet ID: ENR00147

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • T-cell-specific surface glycoprotein CD28
  • Tp44
  • CD80-R
  • CD86-R
  • CD28

General information

  • CD28 costimulation is essential for CD4-positive T-cell proliferation, survival, interleukin-2 production, and T-helper type-2 development. [1]

Links to other resources

UniProt P10747
Ensembl ENST00000458610

Subunit information

isoform 1 (1 times)

Sequence 
NKILVKQSP MLVAYDNAV NLSCKYSYN 
LFSREFRAS LHKGLDSAV EVCVVYGNY 
SQQLQVYSK TGFNCDGKL GNESVTFYL 
QNLYVNQTD IYFCKIEVM YPPPYLDNE 
KSNGTIIHV KGKHLCPSP LFPGPSKPF 
WVLVVVGGV LACYSLLVT VAFIIFWVR 
SKRSRLLHS DYMNMTPRR PGPTRKHYQ 
PYAPPRDFA AYRS
UniProt P10747-1

Binding hormones

    Anatomical structures with this receptor

    • helper_T_cell_Th1

      Influences

      • positive IL-2
        • CD28 is the primary co-stimulatory receptor for inducing high-level IL-2 production and survival of naive CD4(+) T cells. [2]
    Reference