Status
Please wait ...

Details for receptor: GL-R

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00228

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • GL-R
  • glucagon receptor
  • GCGR

General information

  • The glucagon receptor is similar to the calcitonin and parathyroid hormone receptors. It can transduce signals leading to the accumulation of two different second messengers, cAMP and calcium. [1]
  • Glucagon and the glucagon receptor are a primary source of control over blood glucose concentrations. [1]
  • A missense mutation in the gene coding for glucagon receptor leads to diabetes mellituss type 2. [2]

Links to other resources

UniProt P47871
Ensembl ENST00000400723

Subunit information

glucagon receptor

Sequence 
QPQVPSAQV MDFLFEKWK LYGDQCHHN 
LSLLPPPTE LVCNRTFDK YSCWPDTPA 
NTTANISCP WYLPWHHKV QHRFVFKRC 
GPDGQWVRG PRGQPWRDA SQCQMDGEE 
IEVQKEVAK MYSSFQVMY TVGYSLSLG 
ALLLALAIL GGLSKLHCT RNAIHANLF 
ASFVLKASS VLVIDGLLR TRYSQKIGD 
DLSVSTWLS DGAVAGCRV AAVFMQYGI 
VANYCWLLV EGLYLHNLL GLATLPERS 
FFSLYLGIG WGAPMLFVV PWAVVKCLF 
ENVQCWTSN DNMGFWWIL RFPVFLAIL 
INFFIFVRI VQLLVAKLR ARQMHHTDY 
KFRLAKSTL TLIPLLGVH EVVFAFVTD 
EHAQGTLRS AKLFFDLFL SSFQGLLVA 
VLYCFLNKE VQSELRRRW HRWRLGKVL 
WEERNTSNH RASSSPGHG PPSKELQFG 
RGGGSQDSS AETPLAGGL PRLAESPF

Binding hormones

  • glucagon
    (trough: blood
    )

Anatomical structures with this receptor

  • adipose_tissue

    Induced phenotypes

    • positive regulation of lipid catabolic process
      • Glucagon exerts thermogenic effects on rat BAT possibly via its lipolytic action. [4]
      • It is suggested that there is no major role of glucagon in the control of BAT thermogenesis after 1 week in the cold. [5]
    • Glucagon receptor is expressed in adipose tissue. The biochemical characterization of the rat adipocyte glucagon receptor indicates that it closely resembles the hepatic glucagon receptor. [6]

  • heart

    Induced phenotypes

    • stimulation of inotropic and chronotropic activity

  • kidney

    Induced phenotypes

    • regulation of ion transport and electrolyte excretion

  • pancreas

    Induced phenotypes

    • Glucagonoma
      • Glucagonoma is a tumor of the alpha cells of the pancreas that results in an overproduction of the hormone glucagon. Alpha cell tumors are commonly associated with glucagonoma syndrome. [7]

  • stomach

    Influences

    • positive ghrelin
      • These results suggest that glucagon stimulates acute release of both forms of ghrelin and thereafter upregulates synthesis and release of desacyl-ghrelin in the rat stomach. [8]

  • small_intestine

  • thyroid_gland

  • skeleton_muscle

    Induced phenotypes

    • maintaining glucose homeostasis

  • hepatocyte

    Induced phenotypes

    • glycogenolysis
      • Glucagon stimulates glycogenolysis in liver, resulting in elevation of plasma glucose. [9]
    • gluconeogenesis
      • Glucagon stimulates gluconeogenesis in liver, resulting in elevation of plasma glucose. [9]
    • maintainence of serum glucose concentration
      • Glucagon has a critical role in maintaining serum glucose concentration. [9]
Reference