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Details for receptor: PPAR-gamma1

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EndoNet ID: ENR00435

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Synonyms

  • PPAR gamma 1
  • peroxisome proliferator activated receptor gamma 1
  • PPAR-gamma1

General information

  • Liver and muscle express PPAR gamma 1 at much lower levels, although tissue-specific gene disruption suggests that PPAR gamma 1 expression in these tissues may be functionally relevant. [1]
  • PPARgamma2, harboring an additional 30 amino acids at its N-terminal end, is expressed specifically in adipocytes, whereas PPARgamma1 is also relatively abundant in macrophages, colon epithelia, and endothelium. [1]

Links to other resources

UniProt P37231-2
Ensembl ENST00000455517

Subunit information

PPAR gamma isoform 1

Sequence 
MVDTEMPFW PTNFGISSV DLSVMEDHS 
HSFDIKPFT TVDFSSIST PHYEDIPFT 
RTDPVVADY KYDLKLQEY QSAIKVEPA 
SPPYYSEKT QLYNKPHEE PSNSLMAIE 
CRVCGDKAS GFHYGVHAC EGCKGFFRR 
TIRLKLIYD RCDLNCRIH KKSRNKCQY 
CRFQKCLAV GMSHNAIRF GRMPQAEKE 
KLLAEISSD IDQLNPESA DLRALAKHL 
YDSYIKSFP LTKAKARAI LTGKTTDKS 
PFVIYDMNS LMMGEDKIK FKHITPLQE 
QSKEVAIRI FQGCQFRSV EAVQEITEY 
AKSIPGFVN LDLNDQVTL LKYGVHEII 
YTMLASLMN KDGVLISEG QGFMTREFL 
KSLRKPFGD FMEPKFEFA VKFNALELD 
DSDLAIFIA VIILSGDRP GLLNVKPIE 
DIQDNLLQA LELQLKLNH PESSQLFAK 
LLQKMTDLR QIVTEHVQL LQVIKKTET 
DMSLHPLLQ EIYKDLY
UniProt P37231-2

Binding hormones

    Anatomical structures with this receptor

    • fat_cell

      Induced phenotypes

      • regulation of glucose homeostasis
        • PPAR-gamma is expressed in human fat, one tissue where most of the insulin-stimulated glucose uptake occurs. [2]

    • adipose_tissue

      Induced phenotypes

      • regulation of fat cell differentiation
        • PPARγ expression is observed in adipose tissue in rodents. Its expression is induced early in differentiation of 3T3-L1 preadipocytes into adipocytes, and its overexpression in fibroblasts induces them to differentiate into adipocytes. [3]

    • macrophage

    • colon

    • epithelial_cell

    • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • muscle

    Reference