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Details for receptor: GFR-alpha-4

EndoNet ID: ENR00489

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Synonyms

  • GFRalpha4
  • GFRA4
  • persephin receptor
  • GFR-alpha-4
  • GDNF family receptor alpha-4

General information

  • GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. [1]
  • Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells. [2]

Links to other resources

UniProt Q9GZZ7
Ensembl ENST00000412824

Subunit information

GFRalpha4b

Sequence
VGGNRCVDA AEACTADAR CQRLRSEYV 
AQCLGRAAQ GGCPRARCR RALRRFFAR 
GPPALTHAL LFCPCAGPA CAERRRQTF 
VPSCAFSGP GPAPPSCLE PLNFCERSR 
VCRCARAAA GPWRGWGRG LSPAHRPPA 
AQASPPGLS GLVHPSAQR PRRLPAGPG 
RPLPARLRG PRGVPAGTA VTPNYVDNV 
SARVAPWCD CGASGNRRE DCEAFRGLF 
TRNRCLDGA IQAFASGWP PVLLDQLNP 
QGDPEHSLL QVSSTG
UniProt Q9GZZ7-1

Binding hormones

  • persephin

Anatomical structures with this receptor

  • thyroid_gland

Reference