Status
Please wait ...

Details for receptor: GHRH-R

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00574

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • growth hormone releasing hormone receptor
  • GHRHR
  • growth hormone releasing factor receptor
  • GHRFR
  • GHRH-R
  • GRF receptor

General information

  • Unrelated to GHS-R. [1]
  • G-Protein coupled receptor with 7 putative transmembrane domains [2]

Links to other resources

UniProt Q02643
Ensembl ENST00000434774

Subunit information

Sequence 
MDRRMWGAH VFCVLSPLP TVLGHMHPE 
CDFITQLRE DESACLQAA EEMPNTTLG 
CPATWDGLL CWPTAGSGE WVTLPCPDF 
FSHFSSESG AVKRDCTIT GWSEPFPPY 
PVACPVPLE LLAEEESYF STVKIIYTV 
GHSISIVAL FVAITILVA LRRLHCPRN 
YVHTQLFTT FILKAGAVF LKDAALFHS 
DDTDHCSFS TVLCKVSVA ASHFATMTN 
FSWLLAEAV YLNCLLAST SPSSRRAFW 
WLVLAGWGL PVLFTGTWV SCKLAFEDI 
ACWDLDDTS PYWWIIKGP IVLSVGVNF 
GLFLNIIRI LVRKLEPAQ GSLHTQSQY 
WRLSKSTLF LIPLFGIHY IIFNFLPDN 
AGLGIRLPL ELGLGSFQG FIVAILYCF 
LNQEVRTEI SRKWHGHDP ELLPAWRTR 
AKWTTPSRS AAKVLT

Binding hormones

  • GHRH
    (trough: blood
    )

Anatomical structures with this receptor

  • pituitary_gland_of_diencephalon

    Induced phenotypes

    • dwarfism

  • acidophil_somatotroph_cell_of_anterior_pituitary

    Influences

    • positive GH

    Induced phenotypes

    • Growth hormone deficiency
      • One cause of growth hormone deficiency is a mutation in the GHRH-R gene. [3]
    • dwarfism

  • adenohypophysis

    Induced phenotypes

    • dwarfism
      • dwarfism of Sindh [4]
Reference