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Details for receptor: OPG

EndoNet ID: ENR00582

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Synonyms

  • OPG
  • osteoprotegerin
  • osteoclastogenesis inhibitory factor
  • OCIF
  • TNFRSF11B
  • PRG
  • TR1

General information

  • Osteoprotegerin (OPG) and decoy receptor 3 (DcR) are soluble members of the tumor necrosis factor receptor (TNFR) superfamily. [1]
  • Osteoprotegerin (OPG) is an antiresorptive cytokine and a key regulator of osteoclastogenesis and activity. [2]
  • It is a soluble "decoy" receptor for tumor necrosis factor-related apoptosis-inducing ligand and ligand of the receptor activator of NF-kappaB. [3]
  • OPG is downregulated by glucocorticoids and cyclosporine A. [2]
  • Osteoprotegerin, a member of the TNF-receptor family expressed by osteoblasts, has documented effects on the regulation of bone metabolism. OPG inhibits bone resorption and binds with strong affinity to its ligand RANKL, thereby preventing RANKL from binding to its receptor RANK. This system is regulated by calcium-modifying hormones. OPG may also be pivotal in modulating the immune system. [4]
  • OPG also acts as an important regulatory molecule in the vasculature. [5]
  • Osteoprotegerin inhibits proliferation of myeloid progenitor cells. [1]
  • OPG is the inhibitor of osteoclastogenesis. [6]

Links to other resources

UniProt O00300
Ensembl ENST00000297350

Subunit information

Osteoprotegerin mature peptide

Sequence
PCPDHYYTD SWHTSDECL YCSPVCKEL 
QYVKQECNR THNRVCECK EGRYLEIEF 
CLKHRSCPP GFGVVQAGT PERNTVCKR 
CPDGFFSNE TSSKAPCRK HTNCSVFGL 
LLTQKGNAT HDNICSGNS ESTQKCGID 
VTLCEEAFF RFAVPTKFT PNWLSVLVD 
NLPGTKVNA ESVERIKRQ HSSQEQTFQ 
LLKLWKHQN KDQDIVKKI IQDIDLCEN 
SVQRHIGHA NLTFEQLRS LMESLPGKK 
VGAEDIEKT IKACKPSDQ ILKLLSLWR 
IKNGDQDTL KGLMHALKH SKTYHFPKT 
VTQSLKKTI RFLHSFTMY KLYQKLFLE 
MIGNQVQSV KISCL

Binding hormones

  • RANKL
    • Osteoblastic cells express a cell-bound and a soluble form of RANKL as well as the soluble neutralizing receptor, OPG. [7]

Anatomical structures with this receptor

  • osteoclast

    Induced phenotypes

    • inhibition of osteoclast differentation
  • osteoblast

Reference