Status
Please wait ...

Details for receptor: TLR8

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00589

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • TLR8
  • toll like receptor 8

General information

  • Participates in the innate immune response to microbial agents. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [1]

Links to other resources

UniProt Q9NR97
Ensembl ENST00000311912

Subunit information

Sequence 
EENFSRSYP CDEKKQNDS VIAECSNRR 
LQEVPQTVG KYVTELDLS DNFITHITN 
ESFQGLQNL TKINLNHNP NVQHQNGNP 
GIQSNGLNI TDGAFLNLK NLRELLLED 
NQLPQIPSG LPESLTELS LIQNNIYNI 
TKEGISRLI NLKNLYLAW NCYFNKVCE 
KTNIEDGVF ETLTNLELL SLSFNSLSH 
VPPKLPSSL RKLFLSNTQ IKYISEEDF 
KGLINLTLL DLSGNCPRC FNAPFPCVP 
CDGGASINI DRFAFQNLT QLRYLNLSS 
TSLRKINAA WFKNMPHLK VLDLEFNYL 
VGEIASGAF LTMLPRLEI LDLSFNYIK 
GSYPQHINI SRNFSKLLS LRALHLRGY 
VFQELREDD FQPLMQLPN LSTINLGIN 
FIKQIDFKL FQNFSNLEI IYLSENRIS 
PLVKDTRQS YANSSSFQR HIRKRRSTD 
FEFDPHSNF YHFTRPLIK PQCAAYGKA 
LDLSLNSIF FIGPNQFEN LPDIACLNL 
SANSNAQVL SGTEFSAIP HVKYLDLTN 
NRLDFDNAS ALTELSDLE VLDLSYNSH 
YFRIAGVTH HLEFIQNFT NLKVLNLSH 
NNIYTLTDK YNLESKSLV ELVFSGNRL 
DILWNDDDN RYISIFKGL KNLTRLDLS 
LNRLKHIPN EAFLNLPAS LTELHINDN 
MLKFFNWTL LQQFPRLEL LDLRGNKLL 
FLTDSLSDF TSSLRTLLL SHNRISHLP 
SGFLSEVSS LKHLDLSSN LLKTINKSA 
LETKTTTKL SMLELHGNP FECTCDIGD 
FRRWMDEHL NVKIPRLVD VICASPGDQ 
RGKSIVSLE LTTCVSDVT AVILFFFTF 
FITTMVMLA ALAHHLFYW DVWFIYNVC 
LAKVKGYRS LSTSQTFYD AYISYDTKD 
ASVTDWVIN ELRYHLEES RDKNVLLCL 
EERDWDPGL AIIDNLMQS INQSKKTVF 
VLTKKYAKS WNFKTAFYL ALQRLMDEN 
MDVIIFILL EPVLQHSQY LRLRQRICK 
SSILQWPDN PKAEGLFWQ TLRNVVLTE 
NDSRYNNMY VDSIKQY

Binding hormones

    Anatomical structures with this receptor

    • dendritic_cell_in_lymphoid_tissues

    • leukocyte

    • monocyte

    • cholangiocyte

    • macrophage

      Influences

      • positive IL-1 beta
        • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [2]
    Reference