Status
Please wait ...

Details for receptor: TLR7

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00591

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • toll-like receptor 7
  • TLR7

General information

  • Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. [1]
  • Plasmacytoid dendritic cells express only TLR7 and high levels of TLR9 mRNA. [2]
  • Participates in the innate immune response to microbial agents. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [1]

Links to other resources

UniProt Q9NYK1
Ensembl ENST00000380659

Subunit information

Sequence 
ARWFPKTLP CDVTLDVPK NHVIVDCTD 
KHLTEIPGG IPTNTTNLT LTINHIPDI 
SPASFHRLD HLVEIDFRC NCVPIPLGS 
KNNMCIKRL QIKPRSFSG LTYLKSLYL 
DGNQLLEIP QGLPPSLQL LSLEANNIF 
SIRKENLTE LANIEILYL GQNCYYRNP 
CYVSYSIEK DAFLNLTKL KVLSLKDNN 
VTAVPTVLP STLTELYLY NNMIAKIQE 
DDFNNLNQL QILDLSGNC PRCYNAPFP 
CAPCKNNSP LQIPVNAFD ALTELKVLR 
LHSNSLQHV PPRWFKNIN KLQELDLSQ 
NFLAKEIGD AKFLHFLPS LIQLDLSFN 
FELQVYRAS MNLSQAFSS LKSLKILRI 
RGYVFKELK SFNLSPLHN LQNLEVLDL 
GTNFIKIAN LSMFKQFKR LKVIDLSVN 
KISPSGDSS EVGFCSNAR TSVESYEPQ 
VLEQLHYFR YDKYARSCR FKNKEASFM 
SVNESCYKY GQTLDLSKN SIFFVKSSD 
FQHLSFLKC LNLSGNLIS QTLNGSEFQ 
PLAELRYLD FSNNRLDLL HSTAFEELH 
KLEVLDISS NSHYFQSEG ITHMLNFTK 
NLKVLQKLM MNDNDISSS TSRTMESES 
LRTLEFRGN HLDVLWREG DNRYLQLFK 
NLLKLEELD ISKNSLSFL PSGVFDGMP 
PNLKNLSLA KNGLKSFSW KKLQCLKNL 
ETLDLSHNQ LTTVPERLS NCSRSLKNL 
ILKNNQIRS LTKYFLQDA FQLRYLDLS 
SNKIQMIQK TSFPENVLN NLKMLLLHH 
NRFLCTCDA VWFVWWVNH TEVTIPYLA 
TDVTCVGPG AHKGQSVIS LDLYTCELD 
LTNLILFSL SISVSLFLM VMMTASHLY 
FWDVWYIYH FCKAKIKGY QRLISPDCC 
YDAFIVYDT KDPAVTEWV LAELVAKLE 
DPREKHFNL CLEERDWLP GQPVLENLS 
QSIQLSKKT VFVMTDKYA KTENFKIAF 
YLSHQRLMD EKVDVIILI FLEKPFQKS 
KFLQLRKRL CGSSVLEWP TNPQAHPYF 
WQCLKNALA TDNHVAYSQ VFKETV

Binding hormones

    Anatomical structures with this receptor

    • brain

    • placenta

    • spleen

    • stomach

    • small_intestine

    • lung

    • monocyte

    • dendritic_cell_in_lymphoid_tissues

      Influences

      • positive IFN-alpha
      • positive IFN-beta

    • cholangiocyte

    • macrophage

      Influences

      • positive IL-1 beta
        • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [3]
    Reference