Status
Please wait ...

Details for receptor: TLR10

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00592

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • toll-like receptor 10
  • TLR10

General information

  • Participates in the innate immune response to microbial agents. Acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [1]
  • Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines. [1]

Links to other resources

UniProt Q9BXR5
Ensembl ENST00000361424

Subunit information

Sequence 
DAPELPEER ELMTNCSNM SLRKVPADL 
TPATTTLDL SYNLLFQLQ SSDFHSVSK 
LRVLILCHN RIQQLDLKT FEFNKELRY 
LDLSNNRLK SVTWYLLAG LRYLDLSFN 
DFDTMPICE EAGNMSHLE ILGLSGAKI 
QKSDFQKIA HLHLNTVFL GFRTLPHYE 
EGSLPILNT TKLHIVLPM DTNFWVLLR 
DGIKTSKIL EMTNIDGKS QFVSYEMQR 
NLSLENAKT SVLLLNKVD LLWDDLFLI 
LQFVWHTSV EHFQIRNVT FGGKAYLDH 
NSFDYSNTV MRTIKLEHV HFRVFYIQQ 
DKIYLLLTK MDIENLTIS NAQMPHMLF 
PNYPTKFQY LNFANNILT DELFKRTIQ 
LPHLKTLIL NGNKLETLS LVSCFANNT 
PLEHLDLSQ NLLQHKNDE NCSWPETVV 
NMNLSYNKL SDSVFRCLP KSIQILDLN 
NNQIQTVPK ETIHLMALR ELNIAFNFL 
TDLPGCSHF SRLSVLNIE MNFILSPSL 
DFVQSCQEV KTLNAGRNP FRCTCELKN 
FIQLETYSE VMMVGWSDS YTCEYPLNL 
RGIRLKDVH LHELSCNTA LLIVTIVVI 
MLVLGLAVA FCCLHFDLP WYLRMLGQC 
TQTWHRVRK TTQEQLKRN VRFHAFISY 
SEHDSLWVK NELIPNLEK EDGSILICL 
YESYFDPGK SISENIVSF IEKSYKSIF 
VLSPNFVQN EWCHYEFYF AHHNLFHEN 
SDHIILILL EPIPFYCIP TRYHKLKAL 
LEKKAYLEW PKDRRKCGL FWANLRAAI 
NVNVLATRE MYELQTFTE LNEESRGST 
ISLMRTDCL

Binding hormones

    Anatomical structures with this receptor

    • spleen

    • lymph_node

    • thymus

    • tonsil

    • lung

    • monocyte

    • cholangiocyte

    • macrophage

      Influences

      • positive IL-1 beta
        • IL-1β is first synthesized as biologically-inactive precursor (pro-IL-1β) in response to Toll-like receptor (TLR) agonists in macrophages. [2]
    Reference