Status
Please wait ...

Details for receptor: M-CSF-1-R

  • Top
  • General information
  • Subunits
    •
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR00595

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • macrophage colony stimulating factor I receptor
  • M-CSF-1-R
  • CSF-1R
  • CSF1R
  • C-FMS
  • MCSF1R

General information

  • C-fms is expressed at a late stage during osteoclast development. After initiating its expression, mature osteoclasts typically continue to express c-fms transcripts at high levels. [1]
  • Expressed in bone marrow and in differentiated blood mononuclear cells. [2]
  • The CSF-1 receptor (c-fms) is expressed on primitive multipotent hematopoietic cells, phagocyte progenitor cells, monoblasts, promonocytes, monocytes and tissue macrophages. [3]
  • This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor. [2]

Links to other resources

UniProt P07333
Ensembl ENST00000394307

Subunit information

Sequence 
IPVIEPSVP ELVVKPGAT VTLRCVGNG 
SVEWDGPPS PHWTLYSDG SSSILSTNN 
ATFQNTGTY RCTEPGDPL GGSAAIHLY 
VKDPARPWN VLAQEVVVF EDQDALLPC 
LLTDPVLEA GVSLVRVRG RPLMRHTNY 
SFSPWHGFT IHRAKFIQS QDYQCSALM 
GGRKVMSIS IRLKVQKVI PGPPALTLV 
PAELVRIRG EAAQIVCSA SSVDVNFDV 
FLQHNNTKL AIPQQSDFH NNRYQKVLT 
LNLDQVDFQ HAGNYSCVA SNVQGKHST 
SMFFRVVES AYLNLSSEQ NLIQEVTVG 
EGLNLKVMV EAYPGLQGF NWTYLGPFS 
DHQPEPKLA NATTKDTYR HTFTLSLPR 
LKPSEAGRY SFLARNPGG WRALTFELT 
LRYPPEVSV IWTFINGSG TLLCAASGY 
PQPNVTWLQ CSGHTDRCD EAQVLQVWD 
DPYPEVLSQ EPFHKVTVQ SLLTVETLE 
HNQTYECRA HNSVGSGSW AFIPISAGA 
HTHPPDEFL FTPVVVACM SIMALLLLL 
LLLLLYKYK QKPKYQVRW KIIESYEGN 
SYTFIDPTQ LPYNEKWEF PRNNLQFGK 
TLGAGAFGK VVEATAFGL GKEDAVLKV 
AVKMLKSTA HADEKEALM SELKIMSHL 
GQHENIVNL LGACTHGGP VLVITEYCC 
YGDLLNFLR RKAEAMLGP SLSPGQDPE 
GGVDYKNIH LEKKYVRRD SGFSSQGVD 
TYVEMRPVS TSSNDSFSE QDLDKEDGR 
PLELRDLLH FSSQVAQGM AFLASKNCI 
HRDVAARNV LLTNGHVAK IGDFGLARD 
IMNDSNYIV KGNARLPVK WMAPESIFD 
CVYTVQSDV WSYGILLWE IFSLGLNPY 
PGILVNSKF YKLVKDGYQ MAQPAFAPK 
NIYSIMQAC WALEPTHRP TFQQICSFL 
QEQAQEDRR ERDYTNLPS SSRSGGSGS 
SSSELEEES SSEHLTCCE QGDIAQPLL 
QPNNYQFC

Binding hormones

  • M-CSF
  • Interleukin-34
    (trough: blood
    )
    • recently, a second ligand for the CSF-1R, IL-34, was described [4]

Anatomical structures with this receptor

  • osteoclast

  • bone_marrow

    Induced phenotypes

    • myeloid cell differentation

  • monocyte

  • hematopoietic_stem_cell

  • monoblast

  • osteoclast

Reference