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Details for receptor: EDAR

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EndoNet ID: ENR00598

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Synonyms

  • EDAR
  • EDA-A1 receptor
  • TNF receptor superfamily member EDAR
  • anhidrotic ectodysplasin receptor 1
  • ectodysplasin-A receptor
  • ectodermal dysplasia receptor
  • downless homolog
  • DL

General information

  • Receptor for EDA isoform A1, but not for EDA isoform A2. [1]
  • Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. [2]
  • Mediates the activation of NF-kappa-B and JNK. [3]
  • NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression. [4]
  • Eda and Edar are associated with the onset of ectodermal patterning and ectodysplasin/edar signaling also regulates the morphogenesis of hair follicles. [5]

Links to other resources

UniProt Q9UNE0
Ensembl ENST00000409271

Subunit information

TNF receptor superfamily member EDAR.

Sequence 
EYSNCGENE YYNQTTGLC QECPPCGPG 
EEPYLSCGY GTKDEDYGC VPCPAEKFS 
KGGYQICRR HKDCEGFFR ATVLTPGDM 
ENDAECGPC LPGYYMLEN RPRNIYGMV 
CYSCLLAPP NTKECVGAT SGASANFPG 
TSGSSTLSP FQHAHKELS GQGHLATAL 
IIAMSTIFI MAIAIVLII MFYILKTKP 
SAPACCTSH PGKSVEAQV SKDEEKKEA 
PDNVVMFSE KDEFEKLTA TPAKPTKSE 
NDASSENEQ LLSRSVDSD EEPAPDKQG 
SPELCLLSL VHLAREKSA TSNKSAGIQ 
SRRKKILDV YANVCGVVE GLSPTELPF 
DCLEKTSRM LSSTYNSEK AVVKTWRHL 
AESFGLKRD EIGGMTDGM QLFDRISTA 
GYSIPELLT KLVQIERLD AVESLCADI 
LEWAGVVPP ASQPHAAS
UniProt Q9UNE0

Binding hormones

    Anatomical structures with this receptor

    • lung

    • skin

      Induced phenotypes

      • ectodermal dyplasia
        • Mutations in EDAR cause ectodermal dysplasias characterized by defective development of exocrine glands, hairs and teeth due to impaired NF-KB signaling. [6]

    • keratinocyte

    • hair_follicle

      Induced phenotypes

      • hair follicle maturation
        • EDAr regulates the transition from active growth to regression (catagen) during hair follicle maturation. [7]
    Reference