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Details for receptor: IL-2R (low affinity)

EndoNet ID: ENR00600

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Synonyms

  • CD25 antigen
  • P55
  • TAC antigen
  • interleukin-2 receptor alpha
  • IL-2Ralpha
  • IL-2R (low affinity)

General information

Links to other resources

UniProt P01589
Ensembl ENST00000447847

Subunit information

  • Noncovalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. [1]
Sequence
ELCDDDPPE IPHATFKAM AYKEGTMLN 
CECKRGFRR IKSGSLYML CTGNSSHSS 
WDNQCQCTS SATRNTTKQ VTPQPEEQK 
ERKTTEMQS PMQPVDQAS LPGHCREPP 
PWENEATER IYHFVVGQM VYYQCVQGY 
RALHRGPAE SVCKMTHGK TRWTQPQLI 
CTGEMETSQ FPGEEKPQA SPEGRPESE 
TSCLVTTTD FQIQTEMAA TMETSIFTT 
EYQVAVAGC VFLLISVLL LSGLTWQRR 
QRKSRRTI

Binding hormones

  • IL-2
    • IL2R-alpha is a low affinity monomer for interleukin-2. [1]

Anatomical structures with this receptor

  • T-lymphocyte

Reference