Status
Please wait ...

Details for receptor: GFR-alpha-2

EndoNet ID: ENR00602

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • GFR-alpha-2
  • TGF-beta-related neurotrophic factor receptor 2
  • NRTNR-alpha
  • neurturin receptor alpha
  • GDNF receptor beta
  • GDNF family receptor alpha 2
  • GDNFR-beta
  • RET ligand 2

General information

  • GFR alpha-2 is a GPI-linked receptor that preferentially binds neurturin, a member of the GDNF family. [1]

Links to other resources

UniProt O00451
Ensembl ENST00000306793

Subunit information

long isoform

  • Isoform 1 is found in both brain and placenta. [2]
Sequence
SPSSLQGPE LHGWRPPVD CVRANELCA 
AESNCSSRY RTLRQCLAG RDRNTMLAN 
KECQAALEV LQESPLYDC RCKRGMKKE 
LQCLQIYWS IHLGLTEGE EFYEASPYE 
PVTSRLSDI FRLASIFSG TGADPVVSA 
KSNHCLDAA KACNLNDNC KKLRSSYIS 
ICNREISPT ERCNRRKCH KALRQFFDR 
VPSEYTYRM LFCSCQDQA CAERRRQTI 
LPSCSYEDK EKPNCLDLR GVCRTDHLC 
RSRLADFHA NCRASYQTV TSCPADNYQ 
ACLGSYAGM IGFDMTPNY VDSSPTGIV 
VSPWCSCRG SGNMEEECE KFLRDFTEN 
PCLRNAIQA FGNGTDVNV SPKGPSFQA 
TQAPRVEKT PSLPDDLSD STSLGTSVI 
TTCTSVQEQ GLKANNSKE LSMCFTELT 
TNIIPGSNK VIKPNSGPS
UniProt O00451-1

Binding hormones

  • GDNF
  • neurturin
  • ART

Anatomical structures with this receptor

  • brain

    Induced phenotypes

    • regulates noxious heat transduction
  • placenta

Reference