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Details for receptor: LRP1

EndoNet ID: ENR00604

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Synonyms

  • LRP1
  • low-density lipoprotein receptor-related protein 1
  • LRP
  • alpha-2-macroglobulin receptor
  • apolipoprotein E receptor

General information

  • Lrp1 interacts with human FZD1, but cannot substitute for Lrp5/6 in activating the canonical Wnt pathway. [1]
  • Large cell surface receptor that removes a variety of ligands from cell surfaces to lysosomes for degradation. [1]

Links to other resources

UniProt Q07954
Ensembl ENST00000393833

Subunit information

Sequence
AIDAPKTCS PKQFACRDQ ITCISKGWR 
CDGERDCPD GSDEAPEIC PQSKAQRCQ 
PNEHNCLGT ELCVPMSRL CNGVQDCMD 
GSDEGPHCR ELQGNCSRL GCQHHCVPT 
LDGPTCYCN SSFQLQADG KTCKDFDEC 
SVYGTCSQL CTNTDGSFI CGCVEGYLL 
QPDNRSCKA KNEPVDRPP VLLIANSQN 
ILATYLSGA QVSTITPTS TRQTTAMDF 
SYANETVCW VHVGDSAAQ TQLKCARMP 
GLKGFVDEH TINISLSLH HVEQMAIDW 
LTGNFYFVD DIDDRIFVC NRNGDTCVT 
LLDLELYNP KGIALDPAM GKVFFTDYG 
QIPKVERCD MDGQNRTKL VDSKIVFPH 
GITLDLVSR LVYWADAYL DYIEVVDYE 
GKGRQTIIQ GILIEHLYG LTVFENYLY 
ATNSDNANA QQKTSVIRV NRFNSTEYQ 
VVTRVDKGG ALHIYHQRR QPRVRSHAC 
ENDQYGKPG GCSDICLLA NSHKARTCR 
CRSGFSLGS DGKSCKKPE HELFLVYGK 
GRPGIIRGM DMGAKVPDE HMIPIENLM 
NPRALDFHA ETGFIYFAD TTSYLIGRQ 
KIDGTERET ILKDGIHNV EGVAVDWMG 
DNLYWTDDG PKKTISVAR LEKAAQTRK 
TLIEGKMTH PRAIVVDPL NGWMYWTDW 
EEDPKDSRR GRLERAWMD GSHRDIFVT 
SKTVLWPNG LSLDIPAGR LYWVDAFYD 
RIETILLNG TDRKIVYEG PELNHAFGL 
CHHGNYLFW TEYRSGSVY RLERGVGGA 
PPTVTLLRS ERPPIFEIR MYDAQQQQV 
GTNKCRVNN GGCSSLCLA TPGSRQCAC 
AEDQVLDAD GVTCLANPS YVPPPQCQP 
GEFACANSR CIQERWKCD GDNDCLDNS 
DEAPALCHQ HTCPSDRFK CENNRCIPN 
RWLCDGDND CGNSEDESN ATCSARTCP 
PNQFSCASG RCIPISWTC DLDDDCGDR 
SDESASCAY PTCFPLTQF TCNNGRCIN 
INWRCDNDN DCGDNSDEA GCSHSCSST 
QFKCNSGRC IPEHWTCDG DNDCGDYSD 
ETHANCTNQ ATRPPGGCH TDEFQCRLD 
GLCIPLRWR CDGDTDCMD SSDEKSCEG 
VTHVCDPSV KFGCKDSAR CISKAWVCD 
GDNDCEDNS DEENCESLA CRPPSHPCA 
NNTSVCLPP DKLCDGNDD CGDGSDEGE 
LCDQCSLNN GGCSHNCSV APGEGIVCS 
CPLGMELGP DNHTCQIQS YCAKHLKCS 
QKCDQNKFS VKCSCYEGW VLEPDGESC 
RSLDPFKPF IIFSNRHEI RRIDLHKGD 
YSVLVPGLR NTIALDFHL SQSALYWTD 
VVEDKIYRG KLLDNGALT SFEVVIQYG 
LATPEGLAV DWIAGNIYW VESNLDQIE 
VAKLDGTLR TTLLAGDIE HPRAIALDP 
RDGILFWTD WDASLPRIE AASMSGAGR 
RTVHRETGS GGWPNGLTV DYLEKRILW 
IDARSDAIY SARYDGSGH MEVLRGHEF 
LSHPFAVTL YGGEVYWTD WRTNTLAKA 
NKWTGHNVT VVQRTNTQP FDLQVYHPS 
RQPMAPNPC EANGGQGPC SHLCLINYN 
RTVSCACPH LMKLHKDNT TCYEFKKFL 
LYARQMEIR GVDLDAPYY NYIISFTVP 
DIDNVTVLD YDAREQRVY WSDVRTQAI 
KRAFINGTG VETVVSADL PNAHGLAVD 
WVSRNLFWT SYDTNKKQI NVARLDGSF 
KNAVVQGLE QPHGLVVHP LRGKLYWTD 
GDNISMANM DGSNRTLLF SGQKGPVGL 
AIDFPESKL YWISSGNHT INRCNLDGS 
GLEVIDAMR SQLGKATAL AIMGDKLWW 
ADQVSEKMG TCSKADGSG SVVLRNSTT 
LVMHMKVYD ESIQLDHKG TNPCSVNNG 
DCSQLCLPT SETTRSCMC TAGYSLRSG 
QQACEGVGS FLLYSVHEG IRGIPLDPN 
DKSDALVPV SGTSLAVGI DFHAENDTI 
YWVDMGLST ISRAKRDQT WREDVVTNG 
IGRVEGIAV DWIAGNIYW TDQGFDVIE 
VARLNGSFR YVVISQGLD KPRAITVHP 
EKGYLFWTE WGQYPRIER SRLDGTERV 
VLVNVSISW PNGISVDYQ DGKLYWCDA 
RTDKIERID LETGENREV VLSSNNMDM 
FSVSVFEDF IYWSDRTHA NGSIKRGSK 
DNATDSVPL RTGIGVQLK DIKVFNRDR 
QKGTNVCAV ANGGCQQLC LYRGRGQRA 
CACAHGMLA EDGASCREY AGYLLYSER 
TILKSIHLS DERNLNAPV QPFEDPEHM 
KNVIALAFD YRAGTSPGT PNRIFFSDI 
HFGNIQQIN DDGSRRITI VENVGSVEG 
LAYHRGWDT LYWTSYTTS TITRHTVDQ 
TRPGAFERE TVITMSGDD HPRAFVLDE 
CQNLMFWTN WNEQHPSIM RAALSGANV 
LTLIEKDIR TPNGLAIDH RAEKLYFSD 
ATLDKIERC EYDGSHRYV ILKSEPVHP 
FGLAVYGEH IFWTDWVRR AVQRANKHV 
GSNMKLLRV DIPQQPMGI IAVANDTNS 
CELSPCRIN NGGCQDLCL LTHQGHVNC 
SCRGGRILQ DDLTCRAVN SSCRAQDEF 
ECANGECIN FSLTCDGVP HCKDKSDEK 
PSYCNSRRC KKTFRQCSN GRCVSNMLW 
CNGADDCGD GSDEIPCNK TACGVGEFR 
CRDGTCIGN SSRCNQFVD CEDASDEMN 
CSATDCSSY FRLGVKGVL FQPCERTSL 
CYAPSWVCD GANDCGDYS DERDCPGVK 
RPRCPLNYF ACPSGRCIP MSWTCDKED 
DCEHGEDET HCNKFCSEA QFECQNHRC 
ISKQWLCDG SDDCGDGSD EAAHCEGKT 
CGPSSFSCP GTHVCVPER WLCDGDKDC 
ADGADESIA AGCLYNSTC DDREFMCQN 
RQCIPKHFV CDHDRDCAD GSDESPECE 
YPTCGPSEF RCANGRCLS SRQWECDGE 
NDCHDQSDE APKNPHCTS PEHKCNASS 
QFLCSSGRC VAEALLCNG QDDCGDSSD 
ERGCHINEC LSRKLSGCS QDCEDLKIG 
FKCRCRPGF RLKDDGRTC ADVDECSTT 
FPCSQRCIN THGSYKCLC VEGYAPRGG 
DPHSCKAVT DEEPFLIFA NRYYLRKLN 
LDGSNYTLL KQGLNNAVA LDFDYREQM 
IYWTDVTTQ GSMIRRMHL NGSNVQVLH 
RTGLSNPDG LAVDWVGGN LYWCDKGRD 
TIEVSKLNG AYRTVLVSS GLREPRALV 
VDVQNGYLY WTDWGDHSL IGRIGMDGS 
SRSVIVDTK ITWPNGLTL DYVTERIYW 
ADAREDYIE FASLDGSNR HVVLSQDIP 
HIFALTLFE DYVYWTDWE TKSINRAHK 
TTGTNKTLL ISTLHRPMD LHVFHALRQ 
PDVPNHPCK VNNGGCSNL CLLSPGGGH 
KCACPTNFY LGSDGRTCV SNCTASQFV 
CKNDKCIPF WWKCDTEDD CGDHSDEPP 
DCPEFKCRP GQFQCSTGI CTNPAFICD 
GDNDCQDNS DEANCDIHV CLPSQFKCT 
NTNRCIPGI FRCNGQDNC GDGEDERDC 
PEVTCAPNQ FQCSITKRC IPRVWVCDR 
DNDCVDGSD EPANCTQMT CGVDEFRCK 
DSGRCIPAR WKCDGEDDC GDGSDEPKE 
ECDERTCEP YQFRCKNNR CVPGRWQCD 
YDNDCGDNS DEESCTPRP CSESEFSCA 
NGRCIAGRW KCDGDHDCA DGSDEKDCT 
PRCDMDQFQ CKSGHCIPL RWRCDADAD 
CMDGSDEEA CGTGVRTCP LDEFQCNNT 
LCKPLAWKC DGEDDCGDN SDENPEECA 
RFVCPPNRP FRCKNDRVC LWIGRQCDG 
TDNCGDGTD EEDCEPPTA HTTHCKDKK 
EFLCRNQRC LSSSLRCNM FDDCGDGSD 
EEDCSIDPK LTSCATNAS ICGDEARCV 
RTEKAAYCA CRSGFHTVP GQPGCQDIN 
ECLRFGTCS QLCNNTKGG HLCSCARNF 
MKTHNTCKA EGSEYQVLY IADDNEIRS 
LFPGHPHSA YEQAFQGDE SVRIDAMDV 
HVKAGRVYW TNWHTGTIS YRSLPPAAP 
PTTSNRHRR QIDRGVTHL NISGLKMPR 
GIAIDWVAG NVYWTDSGR DVIEVAQMK 
GENRKTLIS GMIDEPHAI VVDPLRGTM 
YWSDWGNHP KIETAAMDG TLRETLVQD 
NIQWPTGLA VDYHNERLY WADAKLSVI 
GSIRLNGTD PIVAADSKR GLSHPFSID 
VFEDYIYGV TYINNRVFK IHKFGHSPL 
VNLTGGLSH ASDVVLYHQ HKQPEVTNP 
CDRKKCEWL CLLSPSGPV CTCPNGKRL 
DNGTCVPVP SPTPPPDAP RPGTCNLQC 
FNGGSCFLN ARRQPKCRC QPRYTGDKC 
ELDQCWEHC RNGGTCAAS PSGMPTCRC 
PTGFTGPKC TQQVCAGYC ANNSTCTVN 
QGNQPQCRC LPGFLGDRC QYRQCSGYC 
ENFGTCQMA ADGSRQCRC TAYFEGSRC 
EVNKCSRCL EGACVVNKQ SGDVTCNCT 
DGRVAPSCL TCVGHCSNG GSCTMNSKM 
MPECQCPPH MTGPRCEEH VFSQQQPGH 
IASILIPLL LLLLLVLVA GVVFWYKRR 
VQGAKGFQH QRMTNGAMN VEIGNPTYK 
MYEGGEPDD VGGLLDADF ALDPDKPTN 
FTNPVYATL YMGGHGSRH SLASTDEKR 
ELLGRGPED EIGDPLA
UniProt Q07954

Binding hormones

  • APOE
  • free PSA
  • neutrophil defensin 4

Anatomical structures with this receptor

    Reference