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Details for receptor: trkB

EndoNet ID: ENR00612

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  • NTRK2
  • BDNF/NT-3 growth factors receptor
  • trkB
  • TrkB tyrosine kinase
  • Neurotrophic tyrosine kinase receptor type 2
  • GP145-TrkB

General information

  • Both BDNF and NT-4/5 are ligands for the Trk B receptor. [1]

Links to other resources

UniProt Q16620
Ensembl ENST00000395882

Binding hormones

  • neurotrophin-4
  • brain-derived neurotrophic factor

Anatomical structures with this receptor

  • dorsal_root_ganglion

    Induced phenotypes

    • regulation of feeding behavior
      • TrkB deficient mice display a loss in lumbar dorsal root ganglia. [2]
      • TrkB may play a role in the complex interactions involved in feeding activity of newborn animals. [3]
      • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [3]