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Details for receptor: trkC

EndoNet ID: ENR00613

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Synonyms

  • NT-3 growth factor receptor
  • NTRK3
  • neurotrophic tyrosine kinase
  • trkC

General information

  • This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. [1]

Links to other resources

UniProt Q16288
Ensembl ENST00000394480

Subunit information

Sequence
CPANCVCSK TEINCRRPD DGNLFPLLE 
GQDSGNSNG NANINITDI SRNITSIHI 
ENWRSLHTL NAVDMELYT GLQKLTIKN 
SGLRSIQPR AFAKNPHLR YINLSSNRL 
TTLSWQLFQ TLSLRELQL EQNFFNCSC 
DIRWMQLWQ EQGEAKLNS QNLYCINAD 
GSQLPLFRM NISQCDLPE ISVSHVNLT 
VREGDNAVI TCNGSGSPL PDVDWIVTG 
LQSINTHQT NLNWTNVHA INLTLVNVT 
SEDNGFTLT CIAENVVGM SNASVALTV 
YYPPRVVSL EEPELRLEH CIEFVVRGN 
PPPTLHWLH NGQPLRESK IIHVEYYQE 
GEISEGCLL FNKPTHYNN GNYTLIAKN 
PLGTANQTI NGHFLKEPF PESTDNFIL 
FDEVSPTPP ITVTHKPEE DTFGVSIAV 
GLAAFACVL LVVLFVMIN KYGRRSKFG 
MKGPVAVIS GEEDSASPL HHINHGITT 
PSSLDAGPD TVVIGMTRI PVIENPQYF 
RQGHNCHKP DTYVQHIKR RDIVLKREL 
GEGAFGKVF LAECYNLSP TKDKMLVAV 
KALKDPTLA ARKDFQREA ELLTNLQHE 
HIVKFYGVC GDGDPLIMV FEYMKHGDL 
NKFLRAHGP DAMILVDGQ PRQAKGELG 
LSQMLHIAS QIASGMVYL ASQHFVHRD 
LATRNCLVG ANLLVKIGD FGMSRDVYS 
TDYYRLFNP SGNDFCIWC EVGGHTMLP 
IRWMPPESI MYRKFTTES DVWSFGVIL 
WEIFTYGKQ PWFQLSNTE VIECITQGR 
VLERPRVCP KEVYDVMLG CWQREPQQR 
LNIKEIYKI LHALGKATP IYLDILG

Binding hormones

  • neurotrophin 3
    • Receptor for neurotrophin-3 (NT-3). [1]

Anatomical structures with this receptor

  • dorsal_root_ganglion

    Induced phenotypes

    • proprioception
      • TrkC deficient mice display abnormal movements that are athetotic in nature and result in highly abnormal limb postures. This suggests a defect in proprioception, the sensory function that localizes the limbs in space. [2]
      • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [3]
      • Mice lacking trkC have a loss of DRG neurons, this defect might be amongst other responsible for the abnormal movements. [3]
Reference