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Details for receptor: IL-4Ralpha

EndoNet ID: ENR00614

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Synonyms

  • IL4R
  • interleukin-4 receptor alpha chain
  • CD124 antigen
  • IL-4Ralpha

General information

  • Highly expressed in activated T-cells. [1]
  • IL-13R, IL-13Ralpha, and IL-4Ralpha mRNA were repeatedly detected in human Osteoblasts, whereas mRNA for IL-2Rgamma(C) was not detected. [2]
  • Positive labeling for IL-4 receptors was also obtained on nonneoplastic bronchial epithelium. [3]

Links to other resources

UniProt P24394
Ensembl ENST00000449195

Subunit information

membran-bound IL-4 receptor alpha chain

Sequence
MKVLQEPTC VSDYMSIST CEWKMNGPT 
NCSTELRLL YQLVFLLSE AHTCIPENN 
GGAGCVCHL LMDDVVSAD NYTLDLWAG 
QQLLWKGSF KPSEHVKPR APGNLTVHT 
NVSDTLLLT WSNPYPPDN YLYNHLTYA 
VNIWSENDP ADFRIYNVT YLEPSLRIA 
ASTLKSGIS YRARVRAWA QCYNTTWSE 
WSPSTKWHN SYREPFEQH LLLGVSVSC 
IVILAVCLL CYVSITKIK KEWWDQIPN 
PARSRLVAI IIQDAQGSQ WEKRSRGQE 
PAKCPHWKN CLTKLLPCF LEHNMKRDE 
DPHKAAKEM PFQGSGKSA WCPVEISKT 
VLWPESISV VRCVELFEA PVECEEEEE 
VEEEKGSFC ASPESSRDD FQEGREGIV 
ARLTESLFL DLLGEENGG FCQQDMGES 
CLLPPSGST SAHMPWDEF PSAGPKEAP 
PWGKEQPLH LEPSPPASP TQSPDNLTC 
TETPLVIAG NPAYRSFSN SLSQSPCPR 
ELGPDPLLA RHLEEVEPE MPCVPQLSE 
PTTVPQPEP ETWEQILRR NVLQHGAAA 
APVSAPTSG YQEFVHAVE QGGTQASAV 
VGLGPPGEA GYKAFSSLL ASSAVSPEK 
CGFGASSGE EGYKPFQDL IPGCPGDPA 
PVPVPLFTF GLDREPPRS PQSSHLPSS 
SPEHLGLEP GEKVEDMPK PPLPQEQAT 
DPLVDSLGS GIVYSALTC HLCGHLKQC 
HGQEDGGQT PVMASPCCG CCCGDRSSP 
PTTPLRAPD PSPGGVPLE ASLCPASLA 
PSGISEKSK SSSSFHPAP GNAQSSSQT 
PKIVNFVSV GPTYMRVS
UniProt P24394-1

Binding hormones

  • IL-4
    • Receptor-blocking antibodies to IL-4Ralpha inhibited the induction of IL-6 formation by both IL-4 and IL-13, indicating that both cytokines utilize this receptor subunit in signaling. [2]
  • IL-13
    • Receptor-blocking antibodies to IL-4Ralpha inhibited the induction of IL-6 formation by both IL-4 and IL-13, indicating that both cytokines utilize this receptor subunit in signaling. [2]

Anatomical structures with this receptor

  • osteoblast

    Influences

    • negative interleukin 6
      • Receptor-blocking antibodies to IL-4Ralpha inhibited the induction of IL-6 formation by both IL-4 and IL-13. IL-4 was tenfold more potent than IL-13 in inducing both alkaline phosphatase (ALP) activity and IL-6 secretion, whereas the cytokines were equipotent as inhibitors of cell proliferation. [2]
    • negative PGE2
  • T-lymphocyte

  • dendritic_cell_in_lymphoid_tissues_follicular

  • epithelial_cell_with_microvilli

  • bronchial_epithelial_cell

  • B-lymphocyte

Reference