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Details for receptor: IL-10R-alpha

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EndoNet ID: ENR00619

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Synonyms

  • IL-10R1
  • CDw210a antigen
  • IL-10R-A
  • interleukin-10 receptor alpha chain
  • IL-10R-alpha

General information

  • Spleen, thymus, and PBMC, weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels. [1]

Links to other resources

UniProt Q13651
Ensembl ENST00000227752

Subunit information

Sequence 
HGTELPSPP SVWFEAEFF HHILHWTPI 
PNQSESTCY EVALLRYGI ESWNSISNC 
SQTLSYDLT AVTLDLYHS NGYRARVRA 
VDGSRHSNW TVTNTRFSV DEVTLTVGS 
VNLEIHNGF ILGKIQLPR PKMAPANDT 
YESIFSHFR EYEIAIRKV PGNFTFTHK 
KVKHENFSL LTSGEVGEF CVQVKPSVA 
SRSNKGMWS KEECISLTR QYFTVTNVI 
IFFAFVLLL SGALAYCLA LQLYVRRRK 
KLPSVLLFK KPSPFIFIS QRPSPETQD 
TIHPLDEEA FLKVSPELK NLDLHGSTD 
SGFGSTKPS LQTEEPQFL LPDPHPQAD 
RTLGNGEPP VLGDSCSSG SSNSTDSGI 
CLQEPSLSP STGPTWEQQ VGSNSRGQD 
DSGIDLVQN SEGRAGDTQ GGSALGHHS 
PPEPEVPGE EDPAAVAFQ GYLRQTRCA 
EEKATKTGC LEEESPLTD GLGPKFGRC 
LVDEAGLHP PALAKGYLK QDPLEMTLA 
SSGAPTGQW NQPTEEWSL LALSSCSDL 
GISDWSFAH DLAPLGCVA APGGLLGSF 
NSDLVTLPL ISSLQSSE

Binding hormones

  • IL-10
    • Receptor for IL10; binds IL10 with a high affinity. [1]

Anatomical structures with this receptor

  • spleen

  • thymus

  • pancreas

  • skeleton_muscle

  • brain

  • heart

  • kidney

  • placenta

  • lung

  • monocyte

    Influences

    • negative IL-12
      • In LPS-stimulated whole blood and purified monocytes, IL-12(p70) and IL-12B(p40) production are enhanced by IFN-gamma and inhibited by IL-10 and IL-4. [2]
      • IL-10 inhibited p70 completely, and p40 about 10-fold. [2]
    • negative IL-12B
      • IL-10 inhibited IL-12(p70) completely, and IL-12B(p40) about 10-fold. [2]
    • negative IL-12A
      • IL-10 inhibited both IL-12A(p35) and IL-12B(p40) mRNA expression. [2]
      • IL-10 inhibited p35 stronger than p40. [2]
    • negative interleukin 6
      • IL-10 inhibited IL-6 production in LPS-stimulated monocytes. [2]

  • T-lymphocyte

  • neutrophil_granulocyte

    Influences

    • negative IL-8
      • IL-10 blocked the late phase of LTA-mediated neutrophil IL-8 synthesis, whereas the early phase (i.e., 8 hrs after stimulation with LTA) of IL-8 synthesis was insensitive to the anti-inflammatory cytokine. [3]

  • B-lymphocyte

Reference