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Details for receptor: CNTFR

EndoNet ID: ENR00633

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General information

  • In addition to including a CNTF-specific component, known as CNTFR alpha, the CNTF receptor complex utilizes two receptor components, gp130 and LIFR beta, that are shared with members of a family of broadly acting cytokines, including leukemia inhibitory factor (LIF) and interleukin-6 (IL6). [1]

Links to other resources

UniProt P26992
Ensembl ENST00000417345

Binding hormones

  • CNTF
  • CLC
    • CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. [2]

Anatomical structures with this receptor

  • hypothalamus

    Induced phenotypes

    • positive regulation of neurogenesis
      • CNTF treatment increases the expression of anorexigenetic nueuons in the hypothalamus [3]