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Details for receptor: IL-11Ralpha

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EndoNet ID: ENR00634

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http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • interleukin 11 receptor, alpha
  • MGC2146
  • IL-11R-alpha
  • IL-11RA
  • IL-11Ralpha

General information

  • IL-11R alpha and gp130 are expressed in both luminal and glandular epithelium. [1]

Links to other resources

UniProt Q14626
Ensembl ENST00000441545

Subunit information

HCR1, membrane form

  • On ligand binding, forms a multimer complex with IL6ST/gp130. [2]
Sequence 
SPCPQAWGP PGVQYGQPG RSVKLCCPG 
VTAGDPVSW FRDGEPKLL QGPDSGLGH 
ELVLAQADS TDEGTYICQ TLDGALGGT 
VTLQLGYPP ARPVVSCQA ADYENFSCT 
WSPSQISGL PTRYLTSYR KKTVLGADS 
QRRSPSTGP WPCPQDPLG AARCVVHGA 
EFWSQYRIN VTEVNPLGA STRLLDVSL 
QSILRPDPP QGLRVESVP GYPRRLRAS 
WTYPASWPC QPHFLLKFR LQYRPAQHP 
AWSTVEPAG LEEVITDAV AGLPHAVRV 
SARDFLDAG TWSTWSPEA WGTPSTGTI 
PKEIPAWGQ LHTQPEVEP QVDSPAPPR 
PSLQPHPRL LDHRDSVEQ VAVLASLGI 
LSFLGLVAG ALALGLWLR LRRGGKDGS 
PKPGFLASV IPVDRRPGA PNL
UniProt Q14626-1

Binding hormones

  • IL-11
    • The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. [2]

Anatomical structures with this receptor

  • prostate

  • cell_of_endometrium_of_uterus

Reference