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Details for receptor: NGF receptor

EndoNet ID: ENR00635

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Synonyms

  • TNFRSF16
  • p75NTR
  • low-affinity nerve growth factor receptor
  • Gp80-LNGFR
  • NGF receptor
  • NGFR
  • p75 ICD
  • nerve growth factor receptor
  • NTR

General information

  • Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. [1]

Links to other resources

UniProt P08138
Ensembl ENST00000172229

Subunit information

Subunit (2 times)

Sequence
KEACPTGLY THSGECCKA CNLGEGVAQ 
PCGANQTVC EPCLDSVTF SDVVSATEP 
CKPCTECVG LQSMSAPCV EADDAVCRC 
AYGYYQDET TGRCEACRV CEAGSGLVF 
SCQDKQNTV CEECPDGTY SDEANHVDP 
CLPCTVCED TERQLRECT RWADAECEE 
IPGRWITRS TPPEGSDST APSTQEPEA 
PPEQDLIAS TVAGVVTTV MGSSQPVVT 
RGTTDNLIP VYCSILAAV VVGLVAYIA 
FKRWNSCKQ NKQGANSRP VNQTPPPEG 
EKLHSDSGI SVDSQSLHD QQPHTQTAS 
GQALKGDGG LYSSLPPAK REEVEKLLN 
GSAGDTWRH LAGELGYQP EHIDSFTHE 
ACPVRALLA SWATQDSAT LDALLAALR 
RIQRADLVE SLCSESTAT SPV

Binding hormones

  • neurotrophin-4
  • NT
  • neurotrophin 3
  • brain-derived neurotrophic factor
  • NGF

Anatomical structures with this receptor

    Reference