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Details for receptor: Tie2

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  • General information
  • Subunits
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00636

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Synonyms

  • Tie2
  • angiopoietin 1 receptor
  • CD202b antigen
  • p140 TEK
  • TIE 2
  • tunica interna endothelial cell kinase
  • tyrosine-protein kinase receptor TEK
  • tyrosine-protein kinase receptor TIE-2
  • TEK tyrosine kinase

General information

  • Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. [1]
  • Predominantly expressed in endothelial cells and their progenitors, the angioblasts. [1]
  • Strong staining in unstimulated LSEC and very strong staining in stimulated LSEC. [2]

Links to other resources

UniProt Q02763
Ensembl ENST00000406359

Subunit information

Sequence 
AMDLILINS LPLVSDAET SLTCIASGW 
RPHEPITIG RDFEALMNQ HQDPLEVTQ 
DVTREWAKK VVWKREKAS KINGAYFCE 
GRVRGEAIR IRTMKMRQQ ASFLPATLT 
MTVDKGDNV NISFKKVLI KEEDAVIYK 
NGSFIHSVP RHEVPDILE VHLPHAQPQ 
DAGVYSARY IGGNLFTSA FTRLIVRRC 
EAQKWGPEC NHLCTACMN NGVCHEDTG 
ECICPPGFM GRTCEKACE LHTFGRTCK 
ERCSGQEGC KSYVFCLPD PYGCSCATG 
WKGLQCNEA CHPGFYGPD CKLRCSCNN 
GEMCDRFQG CLCSPGWQG LQCEREGIP 
RMTPKIVDL PDHIEVNSG KFNPICKAS 
GWPLPTNEE MTLVKPDGT VLHPKDFNH 
TDHFSVAIF TIHRILPPD SGVWVCSVN 
TVAGMVEKP FNISVKVLP KPLNAPNVI 
DTGHNFAVI NISSEPYFG DGPIKSKKL 
LYKPVNHYE AWQHIQVTN EIVTLNYLE 
PRTEYELCV QLVRRGEGG EGHPGPVRR 
FTTASIGLP PPRGLNLLP KSQTTLNLT 
WQPIFPSSE DDFYVEVER RSVQKSDQQ 
NIKVPGNLT SVLLNNLHP REQYVVRAR 
VNTKAQGEW SEDLTAWTL SDILPPQPE 
NIKISNITH SSAVISWTI LDGYSISSI 
TIRYKVQGK NEDQHVDVK IKNATIIQY 
QLKGLEPET AYQVDIFAE NNIGSSNPA 
FSHELVTLP ESQAPADLG GGKMLLIAI 
LGSAGMTCL TVLLAFLII LQLKRANVQ 
RRMAQAFQN VREEPAVQF NSGTLALNR 
KVKNNPDPT IYPVLDWND IKFQDVIGE 
GNFGQVLKA RIKKDGLRM DAAIKRMKE 
YASKDDHRD FAGELEVLC KLGHHPNII 
NLLGACEHR GYLYLAIEY APHGNLLDF 
LRKSRVLET DPAFAIANS TASTLSSQQ 
LLHFAADVA RGMDYLSQK QFIHRDLAA 
RNILVGENY VAKIADFGL SRGQEVYVK 
KTMGRLPVR WMAIESLNY SVYTTNSDV 
WSYGVLLWE IVSLGGTPY CGMTCAELY 
EKLPQGYRL EKPLNCDDE VYDLMRQCW 
REKPYERPS FAQILVSLN RMLEERKTY 
VNTTLYEKF TYAGIDCSA EEAA

Binding hormones

  • ANG-1
    • Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. [1]
  • ANG-2
    • Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. [1]
  • ANG-4
    • Binds to tyrosine-protein kinase receptor TIE2 and activates it. [1]

Anatomical structures with this receptor

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • angioblast

  • lung

  • placenta

  • brain

  • kidney

  • sinusoidal_endothelial_cell

Reference