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Details for receptor: EPHB4

EndoNet ID: ENR00644

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Synonyms

  • Chk
  • EPHB4
  • ephrin type-B receptor 4

General information

Links to other resources

UniProt P54760
Ensembl ENST00000432114

Subunit information

Sequence
LEETLLNTK LETADLKWV TFPQVDGQW 
EELSGLDEE QHSVRTYEV CDVQRAPGQ 
AHWLRTGWV PRRGAVHVY ATLRFTMLE 
CLSLPRAGR SCKETFTVF YYESDADTA 
TALTPAWME NPYIKVDTV AAEHLTRKR 
PGAEATGKV NVKTLRLGP LSKAGFYLA 
FQDQGACMA LLSLHLFYK KCAQLTVNL 
TRFPETVPR ELVVPVAGS CVVDAVPAP 
GPSPSLYCR EDGQWAEQP VTGCSCAPG 
FEAAEGNTK CRACAQGTF KPLSGEGSC 
QPCPANSHS NTIGSAVCQ CRVGYFRAR 
TDPRGAPCT TPPSAPRSV VSRLNGSSL 
HLEWSAPLE SGGREDLTY ALRCRECRP 
GGSCAPCGG DLTFDPGPR DLVEPWVVV 
RGLRPDFTY TFEVTALNG VSSLATGPV 
PFEPVNVTT DREVPPAVS DIRVTRSSP 
SSLSLAWAV PRAPSGAVL DYEVKYHEK 
GAEGPSSVR FLKTSENRA ELRGLKRGA 
SYLVQVRAR SEAGYGPFG QEHHSQTQL 
DESEGWREQ LALIAGTAV VGVVLVLVV 
IVVAVLCLR KQSNGREAE YSDKHGQYL 
IGHGTKVYI DPFTYEDPN EAVREFAKE 
IDVSYVKIE EVIGAGEFG EVCRGRLKA 
PGKKESCVA IKTLKGGYT ERQRREFLS 
EASIMGQFE HPNIIRLEG VVTNSMPVM 
ILTEFMENG ALDSFLRLN DGQFTVIQL 
VGMLRGIAS GMRYLAEMS YVHRDLAAR 
NILVNSNLV CKVSDFGLS RFLEENSSD 
PTYTSSLGG KIPIRWTAP EAIAFRKFT 
SASDAWSYG IVMWEVMSF GERPYWDMS 
NQDVINAIE QDYRLPPPP DCPTSLHQL 
MLDCWQKDR NARPRFPQV VSALDKMIR 
NPASLKIVA RENGGASHP LLDQRQPHY 
SAFGSVGEW LRAIKMGRY EESFAAAGF 
GSFELVSQI SAEDLLRIG VTLAGHQKK 
ILASVQHMK SQAKPGTPG GTGGPAPQY

Binding hormones

  • Ephrin-B2
    • EPHB4 is a receptor for the ephrin B2. [1]

Anatomical structures with this receptor

  • placenta

  • vascularendothelial_cell

    Induced phenotypes

    • vasculogenesis
      • Recently, ephrinB2 has been shown to be required for the remodeling of the embryonic vascular system. [1]
      • Because of its exclusive expression on arteries and the complementary expression of one of its cognate receptors, EphB4, on veins, it was suggested that ephrinB2 acts both as a ligand and as a receptor for EphB4. [1]
    • The receptor fo ephrin-B2, Eph-B4, is expressed on venous cells. [1]
Reference